The HEALthy Brain and Child Development Study: Uncovering Root Causes of Chronic Mental and Physical Illness.
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Noncommunicable or chronic illness accounts for the greatest proportion of global morbidity and mortality (burden of disease) over the past 3 decades.1 Many of the risk factors for noncommunicable diseases, such as diabetes, cancers, and mental illness including substance misuse, can be traced to environments and exposures in early life. Understanding the harms associated with air pollutants, ultra-processed foods (UPFs), excessive screen time and social media exposure, poor sleep and stress, and other factors affecting child development and well-being requires large-scale, longitudinal studies with comprehensive phenotypic characterization and the capabilities to process and make the data available to researchers. Currently, 2 studies funded by the National Institutes of Health are poised to answer pressing questions about early life exposures and vulnerability to chronic illness.