← Back to all signals
RESEARCH PAPER ANALYSIS

Comprehensive molecular characterization of craniopharyngiomas using whole transcriptome and spatial transcriptomics approaches.

AI interpretation is pending for this paper.

Open original publication →
PMID40634824
JournalBrain tumor pathology
Publication Date2025-07-09
Ingested2026-08-02 12:04 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Craniopharyngiomas (CPs) are rare benign brain tumors that are classified as WHO grade I, with two subtypes: adamantinomatous craniopharyngioma (ACP) and papillary craniopharyngioma (PCP). ACP is caused by somatic mutations in exon 3 of the CTNNB1 gene activating the Wnt signaling pathway. PCP is associated with somatic BRAF p.V600E mutations activating the MAPK signaling pathway. Understanding their molecular differences is crucial for diagnosis and treatment. This study aimed to analyze common somatic alterations in ACP and PCP using bulk transcriptome sequencing and in situ spatial transcriptomics. RNA sequencing and high-resolution spatial profiling were used to detect mutations and examine gene expression differences among ACP, PCP, and healthy pituitary tissue. Whole transcriptome sequencing was performed on 24 tumor samples, with healthy pituitary data from the GTEx portal. Bioinformatics analysis utilized the CTAT mutation pipeline, with Sanger sequencing for validation. Results confirmed BRAF p.V600E mutations in all PCP samples and CTNNB1 mutations in all ACP samples. Differential gene expression analysis highlighted distinct molecular profiles and reinforced the involvement of Wnt and MAPK signaling. Spatial profiling identified 41 differentially expressed genes between ACP and PCP. This study provides critical insights into CP biology, supporting improved diagnostics and potential therapeutic strategies.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 [Diagnostic and therapeutic analysis of testicular adrenal rest tumor: A report of 21 cases]. Zhonghua nan ke xue = National journal of andrology 65.54 2 Rediscovering neuroblastoma pathology from the perspective of digital pathology and AI: Current challenges and future implications. Pathologica 56.0 3 [Effect of testicular cancer and its treatment on spermatogenic ability and fertility preservation technology: An update]. Zhonghua nan ke xue = National journal of andrology 56.14 4 A clinical prediction model for sepsis in chemotherapy-induced neutropenia among children with acute lymphoblastic leukemia: development and validation. BMC pediatrics 73.94 5 The palliative care needs of adolescents and young adults with a life limiting condition: a systematic review. BMC palliative care 73.0 6 [Imaging differential diagnosis of psammomatoid ossifying fibroma and psammomatous meningioma in the naso-paranasal region]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 28.5 7 A Giant Ovarian Mucinous Cystadenoma in an Adolescent Patient: A Case Report. Cureus 49.9 8 The genetic profile of B-cell acute lymphoblastic leukaemia diagnosed in Pretoria, South Africa: A 10-year retrospective study. Journal of the colleges of medicine of South Africa 67.0 9 Beware of Tall Stature: Growth Hormone Excess Associated with a Rare Parasellar Extra-Axial Tumour-Diagnostic and Management Challenges in a Resource-Limited Setting. European journal of case reports in internal medicine 62.7 10 Dramatic and sustained regression of an inferior vena cava tumor thrombus in a patient with unresectable giant hepatocellular carcinoma following sequential systemic therapy: a case report and literature review. Frontiers in oncology 59.84 11 Hospitalization and mortality burden of human papillomavirus-associated cancers among men in Ecuador: a nationwide population-based study. Frontiers in public health 40.9 12 Inherited bone marrow failure syndromes in childhood: clinical presentation, diagnostic approach, and contemporary management. Frontiers in pediatrics 59.5 13 Standardizing ototoxicity monitoring for children treated with cisplatin: an urgent call to action. Frontiers in oncology 63.42 14 Locally manufactured point-of-care CD19 chimeric antigen receptor T-cell therapy for paediatric relapsed/refractory B-cell acute lymphoblastic leukaemia: a single-centre feasibility experience. Frontiers in oncology 88.86 15 Juvenile idiopathic arthritis and rheumatoid arthritis: a narrative review of age-dependent, subtype-specific immune mechanisms, biomarkers, and treatment strategies. Frontiers in immunology 72.84 16 The prognostic value of the HALP score among patients diagnosed with Hodgkin lymphoma. Medicine 65.8 17 Artificial Intelligence for Brain MRI Diagnosis: A Scoping Review and Evidence-Gap Map Across Neurological Diseases. Current medical imaging 71.5 18 Associated Factors of Post-Traumatic Growth Profiles Among Mothers of Children with Acute Leukemia During Induction Remission: A Latent Class Analysis. Patient preference and adherence 67.16 19 Orbital Diffuse Large B-Cell Lymphoma Masquerading as Periorbital Cellulitis in a Paediatric Patient With Ataxia-Telangiectasia: A Case Report. Case reports in oncological medicine 64.7 20 Assessment of macronutrient status, soil organic carbon, and the risk of heavy metal contamination in the soils of the Sundarbans polyhaline zone, Bangladesh. Environmental geochemistry and health 56.0 21 A Homozygous FOXA1 Variant Links Choreoathetosis, Bronchiectasis, and Anorectal-Axial Anomalies. Movement disorders : official journal of the Movement Disorder Society 56.0 22 Treatment practices for Helicobacter pylori infection among pediatric gastroenterologists in Latin America. Journal of pediatric gastroenterology and nutrition 72.74 23 Real-world paediatric inflammatory bowel disease surgery: International variation in care and practice. Journal of pediatric gastroenterology and nutrition 61.4 24 Successful limb salvage and favorable functional outcome after subtotal scapulectomy and custom 3D-printed reconstruction in a 14-year-old with high-grade osteosarcoma. Journal of surgical case reports 54.0 25 Determinants of non-utilization of cryotherapy among cervical cancer screening-positive women in public health facilities of West Shoa Zone, Oromia, Ethiopia: An unmatched case-control study. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 68.64 26 Transcriptomic changes associated with the antiproliferative effects of indole-3-acetic acid in SH-SY5Y neuroblastoma cells: an exploratory study. Molecular biology reports 56.0 27 Adult esophageal duplication preoperatively diagnosed by endoscopic ultrasonography and treated with thoracoscopic resection: a case report. Clinical journal of gastroenterology 51.4 28 Expression patterns of hypoxia signaling pathway genes and their association with clinical biochemical parameters in acute myeloid leukemia patients of Assam: A case control study. Molecular biology reports 66.0 29 Association of medical play therapy with psychological resilience during chemotherapy in children with malignant lymphoma: a propensity score-weighted retrospective cohort study. Psychology, health & medicine 73.94 30 SPROUT Guidelines for Molecular Profiling for Children with Solid Tumors: A Consensus Recommendation from the American Association for Cancer Research. Clinical cancer research : an official journal of the American Association for Cancer Research 76.5 31 Getting on the "same page": Couples' experiences communicating about hereditary cancer risk and family building decisions. Journal of psychosocial oncology 58.0 32 Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk. Cell genomics 75.85
PATIENT-FRIENDLY SUMMARY

Comprehensive molecular characterization of craniopharyngiomas using whole transcriptome and spatial transcriptomics approaches.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic