[Effect of testicular cancer and its treatment on spermatogenic ability and fertility preservation technology: An update].
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Compared to other kinds of cancer, testicular cancer has a greater potential to negatively affect a man's sperm-producing ability. And chemotherapy and radiotherapy may cause temporary, long-term, or permanent gonadal toxic effects in male patients in the treatment of testicular cancer. Concomitant chemoradiotherapy may cause abnormalities in germ cell DNA, which theoretically increases the risk of childhood diseases, congenital malformations and cancer in offspring. The combination of sperm cryopreservation and assisted reproductive technology is the most mature method of fertility preservation and fertility at present. In addition, testicular tissue cryopreservation technology and spermatogonial stem cell cryopreservation and subsequent in vitro culture provide patients with new options. This article will review the effects of testicular cancer itself and subsequent treatment on spermatogenic ability and current fertility preservation techniques.