Associated Factors of Post-Traumatic Growth Profiles Among Mothers of Children with Acute Leukemia During Induction Remission: A Latent Class Analysis.
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PURPOSE: To identify distinct post-traumatic growth (PTG) profiles among mothers of children with acute leukemia (AL) during the induction remission phase and examine factors associated with profile membership. PATIENTS AND METHODS: In this cross-sectional study, 223 mothers of children newly diagnosed with AL were recruited using convenience sampling at a tertiary specialized hospital in Guangzhou, China, between November 2021 and February 2023. Data were collected using a demographic information form, the Simplified Chinese Post-Traumatic Growth Inventory, Chinese Event Related Rumination Inventory, Social Support Rating Scale, and Simplified Coping Style Questionnaire. Because PTG may vary across its five dimensions, latent class analysis was used to identify distinct subgroups of mothers with different patterns of PTG. Univariate analysis and multinomial logistic regression examined factors associated with class membership. RESULTS: Three profiles were identified: high-growth (n = 42, 18.8%), medium-growth (n = 155, 69.5%), and low-growth (n = 26, 11.7%). With the high-growth group as the reference, higher positive coping scores were associated with lower odds of medium-growth membership (OR = 0.890, 95% CI: 0.827-0.958; P = 0.002). Higher deliberate rumination (OR = 0.906, 95% CI: 0.825-0.994; P = 0.037), social support (OR = 0.881, 95% CI: 0.798-0.972; P = 0.012), and positive coping (OR = 0.825, 95% CI: 0.742-0.916; P < 0.001) were associated with lower odds of low-growth membership. Household income was not significantly associated with class membership after adjustment. CONCLUSION: Three distinct PTG profiles were identified among mothers of children with AL during the induction remission phase. Positive coping, deliberate rumination, and social support were differentially associated with PTG profile membership. These findings may inform individualized nursing interventions, with comprehensive support considered for the low-growth group and strategies to strengthen positive coping for the medium-growth group.