← Back to all signals
RESEARCH PAPER ANALYSIS

Characteristics, treatments, and outcomes of adolescents and adults with neuroblastoma: a retrospective study in China.

AI interpretation is pending for this paper.

Open original publication →
PMID40351327
JournalTherapeutic advances in medical oncology
Publication Date2025-05-09
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND: Neuroblastoma (NB) is rare in adolescents and adults, resulting in limited availability of data. OBJECTIVES: We comprehensively investigated the characteristics, treatments, and outcomes of adolescent and adult patients with NB, aiming to provide a more in-depth insight into this disease. DESIGN: A retrospective, single-center study. METHODS: We retrieved and analyzed the medical data of patients with NB aged 10 years or older at diagnosis who were treated at Sun Yat-sen University Cancer Center between June 2005 and January 2024. RESULTS: Sixty-five patients (30 males and 35 females) were enrolled, with a median age of 20 years (interquartile range, 14-26 years), including 27 patients aged 10-18 years and 38 patients aged >18 years. Most patients were classified as M-stage disease (n = 40, 61.5%), high-risk (n = 42, 64.6%), and poorly differentiated NB (n = 27, 41.5%). Additionally, 3 (6.7%) patients had MYCN amplification, and 5 (25%) had ALK mutations. The genomic landscape revealed that mutations in the cell cycle and DNA repair pathways are related to chemotherapy sensitivity. After induction therapy, 34 (52.3%) patients achieved complete response (CR). The 5-year progression-free survival (PFS) and overall survival (OS) rates were 33.1% ± 6.9% and 55.1% ± 7.6%, respectively. Patients who achieved CR after induction therapy had superior PFS (p = 0.009), with 5-year PFS rates of 44.0% ± 10.6% compared to 18.5% ± 8.5% in non-CR patients. CONCLUSION: Adolescent and adult patients with NB exhibit distinct characteristics, less chemotherapy sensitivity, and poorer outcomes compared to pediatric patients. Achieving CR after induction therapy is associated with better outcomes. Further investigation for new therapies is required.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study. Annals of hematology 66.6 2 Endoscopic techniques for removal of intraorbital foreign bodies - a clinical series. Acta neurochirurgica 60.9 3 Existing 'In-Between': A Qualitative Exploration of Individual, Interpersonal and Structural Influences on Empowerment Among Young Adults With Chronic Health Conditions. Health expectations : an international journal of public participation in health care and health policy 57.5 4 Transcriptome Analysis Identifies a Myeloid-Like Signature in Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia Patients With Poor Response to CD19 Chimeric Antigen Receptor T Cell Therapy. Cancer medicine 83.78 5 Combined ATR and mitotic inhibition is effective against MYCN-amplified neuroblastoma. Molecular cancer therapeutics 59.9 6 Computational identification of phytochemical NMDAR pore-targeting candidates for radiation-induced cognitive decline. In silico pharmacology 63.2 7 Examining the roles of socioeconomic status and relevant health correlates (body mass index, diet quality, and inflammation) for neuropsychological function in young adults. Acta neuropsychiatrica 65.0 8 Unexpected Adverse Events During Anti-GD2 Immunotherapy Following T- and B-Cell Depleted Haploidentical Transplantation in High-Risk Neuroblastoma: A Pediatric Case Report. Pediatric blood & cancer 47.64 9 Feeding, Fear, and Acceptance: Caregivers' Experiences of Nutritional Support During Childhood Cancer Treatment. Pediatric blood & cancer 59.24 10 Cardio-protection and monitoring for early phase clinical trials: Recommendations from the therapeutic advances in childhood leukemia and lymphoma (TACL) consortium. Journal of the National Cancer Institute 82.34 11 Beyond Molecular Diagnosis: Integrating Therapeutic Drug Monitoring and Pharmacogenetics for Precision Use of Tyrosine Kinase Inhibitors in Pediatric Hematological Malignancies. Therapeutic drug monitoring 55.06 12 Re: Erbas IM: Reconsidering the Interpretation of Thyroid Cancer Risk in Pediatric Hashimoto Thyroiditis. Hormone research in paediatrics 47.5 13 Hepatocellular carcinoma screening in a tertiary hospital. What are we missing? Oncology 68.2 14 Infection in Pediatric Auditory Brainstem Implant: A Case Study and Scoping Review. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 51.9 15 Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Cancer cell 48.85 16 Why Complete Pediatric Cancer Registration in Germany Requires Cross-Sector Reporting Obligations: A Registry Comparison Study. Klinische Padiatrie 57.5 17 Nail disorders in pediatric patients: Part 2. Clinical overview, diagnosis and management of inflammatory, pigmentary, and neoplastic etiologies. Journal of the American Academy of Dermatology 54.0 18 The Maternal-Placental-Fetal Liver Axis: A Mechanistic Framework for Understanding Benzene Developmental Hematotoxicity. Reproductive toxicology (Elmsford, N.Y.) 39.62 19 A Pediatric Case of Malignant Melanoma Successfully Treated With Adjuvant Nivolumab. The Journal of dermatology 47.5 20 Management of seizures in patients with brain tumors. Current opinion in neurology 76.7 21 Paraneoplastic Autoimmune Multiorgan Syndrome: Diagnostic Lessons for Pediatricians. Pediatrics 62.0 22 Intraparotid lipoma in a 15-year-old girl: MRI-based diagnosis of a rare parotid lesion. Radiology case reports 56.0 23 Pathways from chronic stress to cognitive decline: A multi-cohort mediation analysis of inflammation and immune-related gene expression. Brain, behavior, & immunity - health 49.1 24 High-Resolution Ultrasound in the Evaluation of Median and Superficial Radial Nerve Involvement in Neurofibromatosis Type 1. Ultrasound quarterly 54.0 25 Pacak-Zhuang syndrome with EPAS1 p.Pro531Leu somatic variant: one case report and literature review. Hematology (Amsterdam, Netherlands) 50.9 26 Beyond the Bones: Primary Prostatic Synovial Sarcoma in a Young Adult. Cureus 65.2 27 Multiple Extensive Odontogenic Keratocysts in a Child With Gorlin-Goltz Syndrome: A Case Report. Cureus 51.4 28 Behavior Change Interventions to Promote Healthy Lifestyles Among Adolescent and Young Adult Childhood Cancer Survivors: A Scoping Review. Cancer reports (Hoboken, N.J.) 61.2 29 [Survey on serum tetanus antibody levels in children with hematological malignancies post-chemotherapy in Zhejiang Province from 2022 to 2023]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 72.6 30 Utility of thyroid nodule to thyroid lobe volume ratio to measure fine needle aspiration cytologic malignancy risk of thyroid nodules in the pediatric population. International journal of pediatric otorhinolaryngology 68.5 31 Implementation of a universal psychosocial screening program across the pediatric cancer treatment trajectory: a standard of care. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 62.74 32 Conjunctival involvement with corneal extension in pediatric mycosis fungoides. Surgical and immunomodulatory management. Archivos de la Sociedad Espanola de Oftalmologia 60.0
PATIENT-FRIENDLY SUMMARY

Characteristics, treatments, and outcomes of adolescents and adults with neuroblastoma: a retrospective study in China.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic