[Survey on serum tetanus antibody levels in children with hematological malignancies post-chemotherapy in Zhejiang Province from 2022 to 2023].
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To dynamically monitor changes in the levels of serum tetanus antibody in children with hematological malignancies before and after chemotherapy, and to evaluate the necessity of re-vaccination with tetanus-toxoid-containing vaccine (TTCVs) post-chemotherapy. A total of 293 children under 15 years old with hematological malignancies hospitalized in the Children's Hospital affiliated with the School of Medicine at Zhejiang University from January 2022 to December 2023 were included as the case group, matched with 293 community-based healthy children of the same age as the control group. The level of tetanus IgG antibody was measured in the case group pre-chemotherapy and 1 month post-chemotherapy, as well as in the control group. The χ² test and t-test were used to compare the differences in the positive rate and geometric mean concentration (GMC) of tetanus IgG antibody among groups. The male-to-female ratios were 1.24∶1 and 1.20∶1, and the mean ages were (6.66±3.66) years and (6.94±3.73) years for the two groups, respectively. The positive rate of tetanus IgG antibody post-chemotherapy (70.99%) was significantly lower than that pre-chemotherapy (84.64%) (χ²=73.10, P<0.001), and also significantly lower than that in the control group (84.98%) (χ²=16.72, P<0.001). The GMC of tetanus IgG antibody post-chemotherapy (0.73±0.11 IU/ml) was significantly lower than that pre-chemotherapy (1.22±0.17 IU/ml) (t=4.61, P<0.001). It was also significantly lower than that of the control group (1.06±0.06 IU/ml) (t=1.98, P=0.048). In conclusion, the level of tetanus IgG antibody in children with tumors 1 month post-chemotherapy decreases compared with that pre-chemotherapy and is lower than that in the healthy population.