Intravitreal Aflibercept for Diffuse Choroidal Hemangioma in Sturge-Weber Syndrome.
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A 16-year-old female with Sturge-Weber syndrome (SWS) presented with decreased vision in the left eye (20/100). Examination and multimodal imaging showed diffuse choroidal hemangioma with choroidal neovascularization and macular edema. Treatment with three monthly injections of intravitreal aflibercept improved vision by 4 lines with complete resolution of the macular edema sustained 4 months after the last injection. A review of the literature showed that this is the first report of successful use of aflibercept to treat macular edema and choroidal neovascularization associated with diffuse choroidal hemangioma in SWS. We suggest that early antivascular endothelial growth factor injections should be considered when faced with choroidal neovascularization associated with diffuse choroidal hemangiomas.