← Back to all signals
RESEARCH PAPER ANALYSIS

Utility of CCR7 to differentiate classic Hodgkin lymphoma and other B-cell lymphomas by flow cytometry and immunohistochemistry.

AI interpretation is pending for this paper.

Open original publication →
PMID39288406
JournalAmerican journal of clinical pathology
Publication Date2025-02-12
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

OBJECTIVES: Classic Hodgkin lymphoma (CHL) is characterized by infrequent neoplastic Hodgkin and Reed-Sternberg (HRS) cells in an inflammatory background. The diagnostic utility of CC-chemokine receptor 7 (CCR7) in CHL was explored using flow cytometry and immunohistochemistry (IHC). METHODS: Neoplastic specimens and non-neoplastic lymph nodes were immunophenotyped and CCR7 expression was measured semiquantitatively by flow cytometry (clone 3D12) and IHC (clone 150503). RESULTS: Our results showed that CCR7 was expressed on HRS cells in the vast majority of CHL cases (45/48 by flow cytometry, 57/59 by IHC) but rarely expressed in neoplastic cells in diffuse large B-cell lymphoma, not otherwise specified (1/25 by flow cytometry, 2/40 by IHC) and nodular lymphocyte predominant Hodgkin lymphoma (0/4 by flow cytometry, 1/13 by IHC). Primary mediastinal large B-cell lymphoma (PMLBCL) revealed weak CCR7 expression by flow cytometry in most cases (8/10) but only occasionally by IHC (2/12). Both cases (2/2) of T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) also showed CCR7 expression detected by flow cytometry compared with IHC (0/7). The HRS cells demonstrated a greater percentage of positive cells and greater antigen intensity than the other B-cell lymphomas by IHC. The expression identified by flow cytometry in PMLBCL and THRLBCL but not by IHC suggests that there may be differences in the detection capabilities of the 2 techniques or the 2 CCR7 clones used. CONCLUSIONS: The expression of CCR7 in HRS cells suggests its potential utility in differentiating CHL from other B-cell lymphomas. Incorporating CCR7 into flow cytometry and IHC panels may further enhance the diagnostic sensitivity of CHL.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 [Diagnostic and therapeutic analysis of testicular adrenal rest tumor: A report of 21 cases]. Zhonghua nan ke xue = National journal of andrology 65.54 2 Rediscovering neuroblastoma pathology from the perspective of digital pathology and AI: Current challenges and future implications. Pathologica 56.0 3 [Effect of testicular cancer and its treatment on spermatogenic ability and fertility preservation technology: An update]. Zhonghua nan ke xue = National journal of andrology 56.14 4 A clinical prediction model for sepsis in chemotherapy-induced neutropenia among children with acute lymphoblastic leukemia: development and validation. BMC pediatrics 73.94 5 The palliative care needs of adolescents and young adults with a life limiting condition: a systematic review. BMC palliative care 73.0 6 [Imaging differential diagnosis of psammomatoid ossifying fibroma and psammomatous meningioma in the naso-paranasal region]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 28.5 7 A Giant Ovarian Mucinous Cystadenoma in an Adolescent Patient: A Case Report. Cureus 49.9 8 The genetic profile of B-cell acute lymphoblastic leukaemia diagnosed in Pretoria, South Africa: A 10-year retrospective study. Journal of the colleges of medicine of South Africa 67.0 9 Beware of Tall Stature: Growth Hormone Excess Associated with a Rare Parasellar Extra-Axial Tumour-Diagnostic and Management Challenges in a Resource-Limited Setting. European journal of case reports in internal medicine 62.7 10 Dramatic and sustained regression of an inferior vena cava tumor thrombus in a patient with unresectable giant hepatocellular carcinoma following sequential systemic therapy: a case report and literature review. Frontiers in oncology 59.84 11 Hospitalization and mortality burden of human papillomavirus-associated cancers among men in Ecuador: a nationwide population-based study. Frontiers in public health 40.9 12 Inherited bone marrow failure syndromes in childhood: clinical presentation, diagnostic approach, and contemporary management. Frontiers in pediatrics 59.5 13 Standardizing ototoxicity monitoring for children treated with cisplatin: an urgent call to action. Frontiers in oncology 63.42 14 Locally manufactured point-of-care CD19 chimeric antigen receptor T-cell therapy for paediatric relapsed/refractory B-cell acute lymphoblastic leukaemia: a single-centre feasibility experience. Frontiers in oncology 88.86 15 Juvenile idiopathic arthritis and rheumatoid arthritis: a narrative review of age-dependent, subtype-specific immune mechanisms, biomarkers, and treatment strategies. Frontiers in immunology 72.84 16 The prognostic value of the HALP score among patients diagnosed with Hodgkin lymphoma. Medicine 65.8 17 Artificial Intelligence for Brain MRI Diagnosis: A Scoping Review and Evidence-Gap Map Across Neurological Diseases. Current medical imaging 71.5 18 Associated Factors of Post-Traumatic Growth Profiles Among Mothers of Children with Acute Leukemia During Induction Remission: A Latent Class Analysis. Patient preference and adherence 67.16 19 Orbital Diffuse Large B-Cell Lymphoma Masquerading as Periorbital Cellulitis in a Paediatric Patient With Ataxia-Telangiectasia: A Case Report. Case reports in oncological medicine 64.7 20 Assessment of macronutrient status, soil organic carbon, and the risk of heavy metal contamination in the soils of the Sundarbans polyhaline zone, Bangladesh. Environmental geochemistry and health 56.0 21 A Homozygous FOXA1 Variant Links Choreoathetosis, Bronchiectasis, and Anorectal-Axial Anomalies. Movement disorders : official journal of the Movement Disorder Society 56.0 22 Treatment practices for Helicobacter pylori infection among pediatric gastroenterologists in Latin America. Journal of pediatric gastroenterology and nutrition 72.74 23 Real-world paediatric inflammatory bowel disease surgery: International variation in care and practice. Journal of pediatric gastroenterology and nutrition 61.4 24 Successful limb salvage and favorable functional outcome after subtotal scapulectomy and custom 3D-printed reconstruction in a 14-year-old with high-grade osteosarcoma. Journal of surgical case reports 54.0 25 Determinants of non-utilization of cryotherapy among cervical cancer screening-positive women in public health facilities of West Shoa Zone, Oromia, Ethiopia: An unmatched case-control study. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 68.64 26 Transcriptomic changes associated with the antiproliferative effects of indole-3-acetic acid in SH-SY5Y neuroblastoma cells: an exploratory study. Molecular biology reports 56.0 27 Adult esophageal duplication preoperatively diagnosed by endoscopic ultrasonography and treated with thoracoscopic resection: a case report. Clinical journal of gastroenterology 51.4 28 Expression patterns of hypoxia signaling pathway genes and their association with clinical biochemical parameters in acute myeloid leukemia patients of Assam: A case control study. Molecular biology reports 66.0 29 Association of medical play therapy with psychological resilience during chemotherapy in children with malignant lymphoma: a propensity score-weighted retrospective cohort study. Psychology, health & medicine 73.94 30 SPROUT Guidelines for Molecular Profiling for Children with Solid Tumors: A Consensus Recommendation from the American Association for Cancer Research. Clinical cancer research : an official journal of the American Association for Cancer Research 76.5 31 Getting on the "same page": Couples' experiences communicating about hereditary cancer risk and family building decisions. Journal of psychosocial oncology 58.0 32 Genome-wide association study meta-analysis identifies susceptibility loci informing Ewing sarcoma etiology and potential mechanisms of risk. Cell genomics 75.85
PATIENT-FRIENDLY SUMMARY

Utility of CCR7 to differentiate classic Hodgkin lymphoma and other B-cell lymphomas by flow cytometry and immunohistochemistry.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic