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RESEARCH PAPER ANALYSIS

Briefing on Investigational Chimeric Antigen Receptor T-Cell Immunotherapies in Pediatric Neoplasms.

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PMID38718427
JournalJournal of pharmacy practice
Publication Date2024-05-08
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

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WHY IT MATTERS

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ABSTRACT

Source abstract

The promising results seen in the treatment of refractory hematologic malignancies with tisagenlecleucel (Kymriah), the pioneering Chimeric Antigen Receptor (CAR) T-cell immunotherapy, has stimulated a fast growth in research and clinical testing of novel CAR-T constructs, targets, and various generations of CAR T-cells. Pharmacists may receive inquiries about active clinical trials or may be contributing to the care of patients participating in these studies. This briefing discusses the on-going clinical trials that explore novel CAR T-cell immunotherapies in pediatric refractory malignancies of hematologic and solid organ origins. It can be valuable in assisting practitioners in navigating the rapidly evolving field of CAR T-cell immunotherapies.

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Therapeutic drug monitoring 55.06 12 Re: Erbas IM: Reconsidering the Interpretation of Thyroid Cancer Risk in Pediatric Hashimoto Thyroiditis. Hormone research in paediatrics 47.5 13 Hepatocellular carcinoma screening in a tertiary hospital. What are we missing? Oncology 68.2 14 Infection in Pediatric Auditory Brainstem Implant: A Case Study and Scoping Review. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 51.9 15 Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Cancer cell 48.85 16 Why Complete Pediatric Cancer Registration in Germany Requires Cross-Sector Reporting Obligations: A Registry Comparison Study. Klinische Padiatrie 57.5 17 Nail disorders in pediatric patients: Part 2. Clinical overview, diagnosis and management of inflammatory, pigmentary, and neoplastic etiologies. 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Ultrasound quarterly 54.0 25 Pacak-Zhuang syndrome with EPAS1 p.Pro531Leu somatic variant: one case report and literature review. Hematology (Amsterdam, Netherlands) 50.9 26 Beyond the Bones: Primary Prostatic Synovial Sarcoma in a Young Adult. Cureus 65.2 27 Multiple Extensive Odontogenic Keratocysts in a Child With Gorlin-Goltz Syndrome: A Case Report. Cureus 51.4 28 Behavior Change Interventions to Promote Healthy Lifestyles Among Adolescent and Young Adult Childhood Cancer Survivors: A Scoping Review. Cancer reports (Hoboken, N.J.) 61.2 29 [Survey on serum tetanus antibody levels in children with hematological malignancies post-chemotherapy in Zhejiang Province from 2022 to 2023]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 72.6 30 Utility of thyroid nodule to thyroid lobe volume ratio to measure fine needle aspiration cytologic malignancy risk of thyroid nodules in the pediatric population. International journal of pediatric otorhinolaryngology 68.5 31 Implementation of a universal psychosocial screening program across the pediatric cancer treatment trajectory: a standard of care. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 62.74 32 Conjunctival involvement with corneal extension in pediatric mycosis fungoides. Surgical and immunomodulatory management. Archivos de la Sociedad Espanola de Oftalmologia 60.0
PATIENT-FRIENDLY SUMMARY

Briefing on Investigational Chimeric Antigen Receptor T-Cell Immunotherapies in Pediatric Neoplasms.

For education only—not personal medical advice.

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