Influencing factors of fertility concerns in cancer patients of childbearing age: a systematic review and meta-analysis.
AI interpretation is pending for this paper.
Open original publication →What the AI sees
Not AI summarized yet.
Research significance
Pending deeper interpretation.
Source abstract
PURPOSE: This study systematically analyzes factors influencing fertility concerns among cancer patients to inform clinical practice. METHODS: We conducted a comprehensive search of PubMed, Web of Science, Embase, Cochrane Library, and Scopus from inception through August 2024 for studies examining factors associated with fertility concerns in cancer patients. Two researchers independently performed literature screening, data extraction, and quality assessment. Meta-analyses were conducted using RevMan 5.4 and Stata 17.0. RESULTS: A total of 13 articles were included, including 11 cross-sectional studies and 2 longitudinal studies, including 3282 patients. which showed that depression (OR = 1.30, 95%CI = 1.14-1.49), higher education level (OR = 1.74, 95%CI = 1.11-2.73), fertility intentions (OR = 5.96, 95%CI = 1.35-26.31), having more than one child (OR = 0.32, 95%CI = 0.23-0.41), being married (OR = 0.44, 95%CI = 0.26-0.75), full-time employment (OR = 1.41, 95%CI = 1.03-1.93), endocrine therapy (OR = 1.31, 95%CI = 1.07-1.62) and reproductive counseling (OR = 1.21, 95%CI=1.01-1.45) were factors associated with fertility concerns in cancer patients. CONCLUSIONS: This study provides the first quantitative evidence that endocrine therapy and prior fertility counseling are significantly associated with elevated fertility concerns, highlighting potential clinical paradoxes and the complex interplay between medical intervention and psychological distress. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD42024582238.