Genetic association analysis of lnc-AMFR-1:1 rs4784659 C > T and neuroblastoma susceptibility in Chinese pediatric patients.
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BACKGROUND: Neuroblastoma, a neuroendocrine tumor of the sympathetic ganglia, is the leading solid extracranial malignancy in children. The lnc-AMFR-1:1 rs4784659 polymorphism in long noncoding RNA (lncRNA) has been reported to be associated with susceptibility to several cancers, but its role in neuroblastoma remains unclear. METHODS: We studied 402 patients with neuroblastoma and 473 cancer-free controls from Jiangsu Province to assess the association between lnc-AMFR-1:1 rs4784659 C > T and neuroblastoma susceptibility using odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: Analysis under any of the genetic models tested failed to reveal a significant link between the rs4784659 C > T polymorphism and neuroblastoma risk (CT vs. CC: adjusted OR = 0.96, 95% CI = 0.73–1.28, P = 0.799; TT vs. CC: adjusted OR = 1.40, 95% CI = 0.77–2.53, P = 0.273; TT/CT vs. CC: adjusted OR = 1.01, 95% CI = 0.77–1.33, P = 0.924; TT vs. CC/CT: adjusted OR = 1.41, 95% CI = 0.79–2.54, P = 0.245). Moreover, stratified analysis revealed no significant associations. CONCLUSION: This study provided no evidence of an association between the lnc-AMFR-1:1 rs4784659 C > T polymorphism and the risk of neuroblastoma. These findings warrant validation in larger and more diverse populations.