Importance of PET Imaging in the Management of Pediatric Patients with Neuroblastoma.
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While 123I-metaiodobenzylguanidine scintigraphy with single-photon emission computed tomography/computed tomography remains the gold standard for the initial diagnosis, staging, treatment response assessment, and surveillance of recurrence in neuroblastoma (NB), PET imaging has emerged as a promising alternative modality. PET provides superior spatial resolution, allowing earlier detection of small lesions and more accurate staging through quantitative analysis. The development of diverse PET radiotracers has further improved diagnostic precision and facilitated treatment planning. Although current clinical evidence for PET in NB is still limited, ongoing advances in tumor-specific PET tracers are likely to expand its role in future clinical practice.