← Back to all signals
RESEARCH PAPER ANALYSIS

Cost-effectiveness of female-only and gender-neutral HPV vaccination strategies in Japan.

AI interpretation is pending for this paper.

Open original publication →
PMID41524327
JournalJournal of medical economics
Publication Date2026-01-12
Ingested2026-08-02 12:05 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

AIMS: This study evaluated the cost-effectiveness of female-only vaccination (FOV) and gender-neutral vaccination strategies (GNV) using 4-valent (4vHPV) and 9-valent HPV (9vHPV) vaccines among adolescents aged 12-16 years in Japan. It provides the first comprehensive assessment of all feasible vaccine-population combinations using a unified dynamic transmission model. MATERIALS AND METHODS: An age- and sex-structured dynamic transmission model simulated HPV transmission and disease progression over 100 years, incorporating cervical, vulvar, vaginal, anal, head and neck, and penile cancers. Six vaccination strategies were evaluated: no further vaccination, FOV with 4vHPV, FOV with 9vHPV, GNV with 9vHPV for females and 4vHPV for males, GNV with 4vHPV for both sexes, and GNV with 9vHPV for both sexes. Analyses adopted a healthcare payer perspective, with costs in 2025 Japanese yen, discounted at 3%. Incremental cost-effectiveness ratios (ICERs) were calculated using a willingness-to-pay threshold of ¥5 million per quality-adjusted life year (QALY). RESULTS: FOV with 4vHPV yielded an ICER of ¥171,725/QALY versus no vaccination, and FOV with 9vHPV yielded ¥1,366,226/QALY versus FOV with 4vHPV - both below the willingness-to-pay threshold. Furthermore, GNV with 9vHPV for both sexes provided the greatest health gains and remained below the threshold (¥3,594,296/QALY) versus FOV with 9vHPV. GNV with 4vHPV and mixed 9vHPV/4vHPV schedules were dominated and excluded. LIMITATIONS: The healthcare payer perspective excludes indirect costs. The model hypothetically includes 9vHPV for boys despite its unavailability for males in Japan. CONCLUSIONS: Both female-only 4vHPV and 9vHPV strategies are cost-effective under Japan's economic standards. Furthermore, GNV with 9vHPV provides greater health benefits and cost-effectiveness.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Epigenetic modulation of NKG2D ligands enhances NKG2D-CAR T cell efficacy in neuroblastoma. Journal of translational medicine 62.6 2 Copenhagen longitudinal study on quality of life in a young adult population with gliomas. Acta neurochirurgica 73.1 3 Implementation science in global paediatric oncology: a scoping review protocol. BMJ open 74.7 4 Genomic Profiling of Pediatric MPNST Reveals Candidate FGFR1 Driver and Incidental Germline BRCA2 Pathogenic Variant. Pediatrics international : official journal of the Japan Pediatric Society 47.5 5 Herpes zoster risk among female survivors of breast cancer in Japan. Breast cancer research : BCR 64.3 6 Childhood-onset parkinsonism, dystonia and severe muscle wasting in a Sudanese girl caused by a novel homozygous DnaJ heat shock protein family (heat shock protein 40) member C6 frameshift variant, with an incidental pathogenic breast cancer 1 gene secondary finding: a case report. Journal of medical case reports 49.0 7 Interaction between microvascular invasion and early recurrence of hepatocellular carcinoma in cirrhosis patients with curative liver resection: a retrospective cohort study. BMC gastroenterology 67.0 8 Clinical spectrum and risk factors for severe arrhythmias in non-surgical pediatric patients: a single-center retrospective study. Journal of cardiothoracic surgery 68.0 9 The lived experiences of reproductive-aged women with polycystic ovary syndrome: a qualitative study. BMC women's health 59.9 10 Adult Presentation of a Large Congenital Pulmonary Airway Malformation Discovered After Traumatic Rib Fractures. Cureus 56.0 11 A Glimpse into the Experience of Intraoperative Squash Smear Cytology of Pediatric Space-Occupying Lesions of the Central Nervous System: A Study from North Indian Tertiary Care Center. Journal of cytology 61.5 12 Long-term clinical outcomes in females with precocious puberty treated with gonadotropin-releasing hormone analogues. Frontiers in endocrinology 68.4 13 Prevalence and genotype distribution of human papillomavirus among 15,224 gynecological outpatients in Xuzhou, China, during 2023-2025. Frontiers in public health 59.5 14 Giant Cystic Lymphangioma of the Transverse Mesocolon in a 7-Year-Old Child: A Case Report. International medical case reports journal 47.5 15 Comparable efficacy of extraoral and intraoral photobiomodulation in preventing oral mucositis during high-dose methotrexate therapy in pediatric oncology: A single-blind randomized controlled trial. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 84.86 16 Premature treatment cessation in pediatric acute myeloid leukemia due to excessive toxicity: clinical experiences and patient outcomes - a case series. Pediatric hematology and oncology 65.06 17 Rare presentation of hydrocephalus occlusus caused by membranous obstruction of the foramina of Magendie and Luschka: a case report. Journal of surgical case reports 47.9 18 Impact of 131I-MIBG dose escalation (12 vs. 18 mCi/kg) during conditioning for autologous hematopoietic stem cell transplantation in pediatric neuroblastoma: a retrospective cohort study. European journal of pediatrics 74.42 19 Invisible Enemy: CMV Retinitis Despite Persistent Blood PCR Negativity in Pediatric AML. Turkish journal of haematology : official journal of Turkish Society of Haematology 47.5 20 A real-world multi-institution experience of standard versus alternative dosing regimens of inotuzumab ozogamicin for relapsed/refractory paediatric B-cell acute lymphoblastic leukaemia. British journal of haematology 68.04 21 Adolescent Chronic Sleep Restriction Induces a Mesolimbic Hypodopaminergic State Associated with Addiction Vulnerability. Sleep 49.7 22 Incidence of intra-axial brain metastases in Eastern Finland. Journal of neuro-oncology 69.0 23 Ciliated hepatic foregut cyst in children and adolescents: a systematic review of clinical presentation, diagnosis, management, and outcomes. Pediatric surgery international 70.0 24 Adolescent M-CSF Administration Provides Durable Protection Against Trauma-Induced PTSD-Like Phenotypes in Male Mice Through Microglia-Dependent Mechanisms. Neurochemical research 57.75 25 Multimodal Combination Treatment in a Patient-Centered Approach is Associated with Improved Outcome in Relapsed/Refractory Sarcomas in Children: A Comparative Single-Institution Real-World Analysis. Oncology and therapy 68.18 26 Familial 46,XX Ovotesticular Differences in Sex Development Associated With an NR5A1 p.Arg92Trp Variant. Hormone research in paediatrics 38.5 27 Protective effect of folic acid supplementation on the proportion of micronucleated erythrocytes in Balb-C mice irradiated with computed tomography. International journal of radiation biology 48.5 28 Educating Pediatric Oncology Clinicians on Sexual Health Care for Adolescents and Young Adults With Cancer: Results From a Proof-of-Concept Study. JCO oncology practice 58.0 29 Effects of the GnRH agonist leuprorelin on liver volume in premenopausal women with severe polycystic liver disease. Hepatology communications 63.5 30 Dynamic Proton arc therapy for paediatric parameningeal rhabdomyosarcoma. Journal of applied clinical medical physics 67.54 31 Late-onset hypothalamic-pituitary dysfunction in a childhood cancer survivor treated with cranial irradiation. JCEM case reports 62.8 32 Late cardiopulmonary morbidity in patients with Hodgkin lymphoma: a retrospective nationwide registry study. Annals of hematology 66.6
PATIENT-FRIENDLY SUMMARY

Cost-effectiveness of female-only and gender-neutral HPV vaccination strategies in Japan.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic