← Back to all signals
RESEARCH PAPER ANALYSIS

Prognostic factors influencing outcomes of allogeneic HCT for AML with monosomal karyotype.

AI interpretation is pending for this paper.

Open original publication →
PMID41493720
JournalInternational journal of hematology
Publication Date2026-01-06
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Monosomal karyotype (MK) comprises chromosomal abnormalities defined as either one single autosomal monosomy with structural abnormalities (MK1) or two or more distinct autosomal monosomies (MK2). MK is a predictive factor for extremely poor prognosis in patients with acute myeloid leukemia (AML), and not all patients are eligible for allogeneic hematopoietic cell transplantation (HCT). Using registry data from the Japan Society for Transplantation and Cellular Therapy, we retrospectively analyzed 892 AML patients with MK who underwent initial HCT between 2000 and 2017. The median follow-up among surviving patients was 3.1 years (range, 0.1-13.8 years). The 3-year overall survival (OS) rate was 26% for the 284 MK1 patients, which was significantly higher than the 10% observed in the 608 MK2 patients (P < 0.001). Multivariate analysis showed that MK subtype, disease status at time of HCT, patient age at HCT, sex, performance status, and year of HCT significantly affected OS. Notably, MK1 was associated with better OS than MK2 in both patients in complete remission (CR) and non-CR patients. Molecular pathogenesis may be different between MK1 and MK2, and further investigation is required to gain biological insight into the impact of MK subtype on post-HCT outcomes.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Late Ischemic Cholangiopathy After Liver Transplantation From a Deceased Donor With Situs Inversus Totalis: A Case Report. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 47.5 2 Lived experiences of parenting-related distress in mothers with gynecological cancer: a descriptive phenomenological study. BMC women's health 58.4 3 Vancomycin Taper-and-Pulse Therapy for Recurrent Clostridioides difficile Infection in Pediatric Acute Lymphoblastic Leukemia Patients Treated With Blinatumomab and Chemotherapy: A Report of Three Cases. Cureus 62.34 4 Percutaneous calcium phosphate cement injection for unicameral bone cysts: mid- to long-term clinical and radiographic outcomes. Frontiers in surgery 63.9 5 Radiographic evidence of thymic involution in hepatocellular carcinoma: a propensity score-matched study in viral cirrhosis. Frontiers in immunology 62.5 6 Case Report: Activated phosphoinositide 3-kinase δ syndrome mimicking Hyper-IgM syndrome: early hepatosplenomegaly as a key diagnostic clue. Frontiers in immunology 56.6 7 Herpes zoster frequency and severity in immunocompromised pediatric populations: a structured narrative review. Frontiers in pediatrics 59.0 8 Recognition and management of early complications in CAR-T cell therapy and virus-specific T-lymphocyte therapy: a practical clinical reference. Frontiers in immunology 75.5 9 Gastric dysbiosis and more severe histological gastritis in symptomatic Helicobacter pylori-infected children and adolescents without ulcers: time to rethink early eradication? Frontiers in microbiology 58.4 10 Surgical management and molecular diagnosis of pediatric cystic nephroma: a single-center case series with implications for DICER1 syndrome surveillance. Translational andrology and urology 56.9 11 Infantile Osteopetrosis with a CLCN7 Variant: An Educational Case Highlighting Integrated Diagnosis and Variant Interpretation. EJIFCC 56.0 12 Plexiform neurofibroma of the scrotum in a 16-year-old male: A case report. Urology case reports 45.5 13 Advanced Imaging Techniques for Early in-Vivo Discrimination of Fibrofolliculomas in Birt-Hogg-Dubé Syndrome. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 57.5 14 Health Behaviors in Adolescent and Young Adult (AYA) Childhood Cancer Survivors: Prevalence, Determinants, and Comparison With Population Controls. Cancer medicine 66.9 15 Mechanism of Gu-Ben-Hua-Shi (AESS) Formula Regulating Autophagy Through Hippo-YAP Pathway in Restoring the Skin Barrier in Atopic Dermatitis. Journal of cellular and molecular medicine 76.35 16 Mapping Psychosocial Determinants for Cancer Onset: An Umbrella Review. Psycho-oncology 74.9 17 Early-onset colorectal cancer burden attributable to early-life obesity from 2000 to 2020 with projections to 2040. Cancer epidemiology 57.5 18 The effect of unique molecular identifier family size using tumor-informed circulating tumor-DNA analysis in childhood cancers. The Journal of molecular diagnostics : JMD 59.6 19 GATA3-driven CDC20 activation facilitates tumor growth and metastasis through suppressing Bax/Bcl-2 ratio and boosting EMT process in neuroblastoma. The Journal of biological chemistry 60.6 20 [Masked pediatric pathological femoral fracture : Case report of a sarcoma-associated femoral fracture after adequate trauma]. Unfallchirurgie (Heidelberg, Germany) 49.9 21 Antiviral therapies are associated with reduced mortality but under-utilized in patients with viral hepatocellular carcinoma: a multinational REAL-HCC study. Hepatology international 61.1 22 Privacy-Preserving Linkage of Distributed Biological, Clinical, and Imaging Data Supporting Artificial Intelligence in Pediatric Oncology. Methods of information in medicine 71.9 23 Risk and benefit for targeted therapy agents in paediatric phase I trials in oncology: a systematic review and meta-analysis protocol. BMJ open 83.72 24 Testicular Tissue Cryopreservation in Prepubertal Boys: Current Advances, Clinical Feasibility, and Future Directions-A Comprehensive Literature Review. Andrology 63.6 25 Opioid limiting law and opioid prescriptions among Medicaid-enrolled survivors of childhood cancer. Journal of the National Cancer Institute 57.5 26 The efficacy of 1064-nm Nd: YAG picosecond laser for Becker's nevus: a retrospective analysis of 49 cases. Lasers in medical science 61.6 27 Recognizing genetic association between Lhermitte-Duclos Disease and Autism Spectrum Disorder in PTEN-related patients: a case report and literature comprehension. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 49.0 28 Incidence and survival of pediatric low-grade gliomas in Switzerland. World journal of pediatrics : WJP 73.92 29 Unmasking phenotypic heterogeneity and extracellular matrix architecture in neuroblastoma through orthotopic xenograft modeling. Translational oncology 53.4 30 Global burden and inequalities of Hodgkin and non-Hodgkin lymphoma among children aged 0-14 years, 1990-2021: a GBD 2021 analysis with forecasts to 2035. Jornal de pediatria 59.9 31 From Kitchen to Clinic: Study protocol for a family-centered, food-as-medicine approach using medically tailored meals and caregiver coaching in pediatric oncology care. Contemporary clinical trials communications 64.4 32 Obesity and Cardiovascular Disease: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2026. Obesity pillars 61.9
PATIENT-FRIENDLY SUMMARY

Prognostic factors influencing outcomes of allogeneic HCT for AML with monosomal karyotype.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic