← Back to all signals
RESEARCH PAPER ANALYSIS

Does financial subsidy equalise cancer genetic testing uptake across socioeconomic groups? A retrospective observational study in Singapore.

AI interpretation is pending for this paper.

Open original publication →
PMID41360469
JournalBMJ open
Publication Date2025-12-05
Ingested2026-08-02 12:05 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

OBJECTIVE: To examine the association between socioeconomic status (SES), financial subsidies and awareness-related factors such as age, cancer stage and family history, and the uptake of cancer genetic testing, with a focus on equitable access to care. DESIGN: Retrospective cohort study. SETTING: Tertiary care cancer genetics service in Singapore. PARTICIPANTS: The study population included 2687 individuals of all ages, genders and ethnicities who attended pretest counselling between 2014 and 2020 and were eligible for genetic testing for hereditary cancer syndromes. PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was the uptake of genetic testing. The main explanatory variables were SES (proxied by Housing Index), subsidy status, age, cancer stage and family history. Analyses examined whether associations varied across SES and age subgroups. RESULTS: Receipt of financial subsidies was strongly associated with testing uptake (adjusted OR 9.15, 95% CI 2.68 to 31.20). Uptake exceeded 90% among subsidised individuals across all socioeconomic strata, compared with 56-68% among non-subsidised individuals, with the largest gains in the lowest SES group (43 vs 28 percentage points (pp) in the highest). The level of subsidy was not associated with uptake. Younger patients (18-39 years) had higher uptake than those aged 60+ (66% vs 57%); patients with advanced cancer (stage IV) had the highest uptake (82% vs 57-66% in earlier stages); and family history was associated with increased uptake, strongest for having a child with cancer (+28 pp). Interaction analysis suggested that the additive effects of subsidies were greatest in lower SES groups and in older adults. CONCLUSIONS: Financial subsidies were strongly associated with higher genetic testing uptake. Awareness indicators like age, cancer stage and family history were associated with higher uptake. The association between subsidies and uptake varied by SES and age, suggesting that subsidies may help reduce disparities and improve equitable access to genetic testing services.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Orofacial Cleft Characteristics in Van der Woude Syndrome: A Retrospective Study in Japan. Congenital anomalies 61.5 2 Spectrum of oral and maxillofacial pathologies in pediatric patients: A decade-long institutional study in South Kerala. Indian journal of pathology & microbiology 49.0 3 A clinicopathological study of gonadal tumors in differences in sex development: Experience from a tertiary care centre. Indian journal of pathology & microbiology 58.4 4 Suprasellar neuroblastoma in an adult: Challenges in neuropathological diagnosis. Indian journal of pathology & microbiology 45.5 5 Hypothalamic hamartoma in a child with Pallister-Hall syndrome: Report of a rare lesion successfully managed with multidisciplinary approach. Indian journal of pathology & microbiology 56.0 6 Orbital neuromuscular choristoma (benign triton tumor) presenting as a painful blind eye: A rare case report. Indian journal of pathology & microbiology 45.5 7 Physical activity and health-related quality of life in women with polycystic ovary syndrome attending fertility clinics in Sri Lanka: a cross-sectional study. BMC women's health 64.0 8 SFRP2+ fibroblasts orchestrate post-chemotherapy remodeling and define a tumor-driven prognostic program, NBTRP, in adrenal neuroblastoma. Cell death & disease 66.14 9 Retrospective CT imaging findings of pediatric colorectal carcinoma with correlative outcomes: a case series. BMC pediatrics 54.5 10 TRAIL orchestrates ThINKK-induced NK cell cytotoxicity against childhood acute lymphoblastic leukemia. Cancer immunology, immunotherapy : CII 61.42 11 Three-dimensional imaging characteristics of odontomas using cone-beam computed tomography: a clinical retrospective study. BMC oral health 63.0 12 Familial tailgut cysts in two sisters presenting with sacral dimple sign: a case report. Journal of medical case reports 49.0 13 Effectiveness of health mediation to promote organised cancer screening among underserved and under-screened populations in Marseille, France: findings from a repeated cross-sectional survey. BMC public health 62.0 14 Subependymal Giant Cell Astrocytoma Mimicking Recurrent Ependymoma: Imaging Clues to the Diagnosis of Tuberous Sclerosis Complex. Cureus 54.0 15 Characterization of chemoresistant cell populations improves risk stratification and therapy prediction in pediatric acute myeloid leukemia. Nature communications 74.0 16 The minipig as a programmable translational platform for experimental oncofertility. Frontiers in oncology 54.1 17 Epidemiology and outcomes in pediatric neuroblastoma: a US population-based study. Frontiers in medicine 70.0 18 Long-term endocrine and reproductive outcomes in female adolescent and young adult survivors after hematopoietic stem cell transplantation for hematological malignancies during childhood or adolescence. Frontiers in endocrinology 67.5 19 Case Report: Diagnostic dilemma: rebound thymic hyperplasia mimicking mediastinal relapse following chemoimmunotherapy in pediatric jejunal Burkitt lymphoma. Frontiers in immunology 61.74 20 Mosaic RASopathies: comprehensive genetic and clinicopathological analysis for diagnosis and management. Frontiers in cell and developmental biology 58.5 21 Primary bronchial fibrous histiocytoma mimicking refractory asthma in a child: A fatal case of misdiagnosis and airway obstruction. Respiratory medicine case reports 61.62 22 Primary pulmonary small cell carcinoma in a 13-year-old boy with prolonged second-hand tobacco smoke exposure: A rare pediatric lung malignancy with a review of reported cases and registry data. Respiratory medicine case reports 64.3 23 Rapidly progressive adult-onset hydroa vacciniforme-like lymphoproliferative disorder associated with Epstein-Barr virus: a case report. Leukemia research reports 51.1 24 Immunohistochemical analysis of phospho-ERK1/2 in odontogenic cysts. Journal of applied oral science : revista FOB 37.0 25 Exercise against cancer: recent advances and open questions. Trends in cancer 70.7 26 Childhood malignancies in inborn errors of immunity: a multicenter cohort study. European journal of pediatrics 68.1 27 Effect of implementation of a clinical checklist on the evaluation of constitutional mismatch repair deficiency in a neurofibromatosis clinic. Journal of community genetics 73.7 28 Tumour-anchored Purkinje-mediated ventricular tachycardia in a child with cardiac rhabdomyoma. Cardiology in the young 33.5 29 Angiographic findings, revascularisations and mortality in childhood cancer survivors with ischaemic heart disease. JNCI cancer spectrum 65.4 30 Lived Experience of Treatment-Related Late Effects After Childhood and Adolescent Cancer. Journal of adolescent and young adult oncology 59.24 31 A Place to Belong: A Comprehensive Review of Adolescent and Young Adult Surgical Oncology Care. Annals of surgical oncology 74.3 32 Imaging of developmental, inflammatory, and benign or malignant neoplastic petrous apex lesions in children: what the radiologist needs to know. La Radiologia medica 55.5
PATIENT-FRIENDLY SUMMARY

Does financial subsidy equalise cancer genetic testing uptake across socioeconomic groups? A retrospective observational study in Singapore.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic