Oral and maxillofacial schwannoma (OMSCH): An institutional study of 102 patients.
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BACKGROUND: Oral and maxillofacial schwannoma (OMSCH) is a benign tumor originating from the Schwann cells of peripheral nerves in the oral and maxillofacial region, whose diagnosis and treatment remain challenging. METHODS: This retrospective study analyzed OMSCH cases treated at our institution from January 2020 to June 2022. Demographics, clinical features, diagnostic methods, surgical approaches, and postoperative pathology were comprehensively evaluated. RESULTS: A total of 102 patients with OMSCH were included, ranging from 8 to 86 years, with a notable female predominance. The parotid gland was the most frequent site of involvement, while tongue was the most commonly affected structure within the oral cavity. Seventy-one patients (69.6 %) had tumors exceeding 2 cm in size. Magnetic resonance imaging (MRI) exhibited the highest diagnostic accuracy (20/46, 43.5 %). Eighty-five patients (83.3 %) underwent complete surgical resection, with intracapsular enucleation primarily employed for facial nerve schwannomas. Postoperative histopathology revealed a characteristic biphasic pattern and prominent S100/SOX10 immunohistochemical staining. Postoperative complications included tongue deviation in one patient and facial paralysis in 17 patients (16.7 %). No recurrences were observed during follow-up (30-69 months). CONCLUSION: OMSCH is a rare tumor with limited diagnostic accuracy. MRI remains the preferred diagnostic modality, and surgical intervention generally results in favorable outcomes.