Tumor Predisposition Syndromes: An Imaging Review.
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Tumor predisposition syndromes (TPS) are inherited cancer syndromes linked to approximately 10% of all cancers and up to 20% pediatric central nervous system (CNS) tumors. TPS manifest with characteristic patterns of neoplasms throughout the body and require targeted, region-specific imaging for surveillance. Advances in cancer genomics have allowed options for therapies targeting specific molecular pathways. This article highlights CNS imaging features of TPS, with additional insights into the underlying genomic alterations that lead to their development.