← Back to all signals
RESEARCH PAPER ANALYSIS

The prognostic implications of CDKN2A/2B deletion in childhood acute lymphoblastic leukemia: a systematic review and meta-analysis.

AI interpretation is pending for this paper.

Open original publication →
PMID40560782
JournalLeukemia & lymphoma
Publication Date2025-06-25
Ingested2026-08-02 12:04 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

This review aimed to evaluate the impact of cyclin-dependent kinases 2 A/2B (CDKN2A/2B) deletion on survival in pediatric acute lymphoblastic leukemia (ALL). We pooled hazard ratios (HRs) and risk ratios (RRs) with 95% CIs, which were calculated using random-effects models. Individual patient data (IPD) were extracted from published survival curves of included studies, and combined HR was estimated. Fourteen studies (n = 2532 subjects) were included. CDKN2A/2B deletion was found to be associated with poor event/disease/relapse-free survivals at both study levels (HR 2.18; 95% CI: 1.46-3.27; I2 51%) and IPD level (HR 3.45; 95% CI 2.76-4.32 and p < 0.001); and poor overall survival at the IPD level (HR 3.22; 95% CI: 1.78-5.84 and p < 0.001). CDKN2A/2B deletion was also associated with a higher risk of poor prednisolone response (RR 1.38; 95% CI: 1.09-1.74; I2 7%) and relapse rates (RR 3.83; 95% CI: 2.76-5.3; I2 -0%). The meta-analysis highlights the negative impact of CDKN2A/2B deletions on disease outcome and treatment response. Hence, incorporating these alterations should improve risk stratification and risk-adapted treatment strategies for childhood ALL.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Impact of Coronavirus 2019 on Breast Cancer Screening in African American Women. Journal of health care for the poor and underserved 69.5 2 Abstracts of the 66th Annual General Conference of the Nigerian Medical Association. Nigerian medical journal : journal of the Nigeria Medical Association 28.5 3 Prognostic factor analysis of CD19 CAR-T therapy followed by hematopoietic stem cell transplantation in relapsed/refractory B-ALL. Clinical and experimental medicine 70.18 4 Epidemiological Trends and Multidrug-Resistant Patterns in Central Line-Associated Bloodstream Infections Among Bone Marrow Transplant Patients at Comprehensive Cancer Center in Jordan: Five-Year Retrospective Study. Immunity, inflammation and disease 68.36 5 Liposomal amphotericin B retrospective multicentre study on mycosis prophylaxis (L-AmB_RUSCO): tolerability and safety of extended-dosing primary antifungal prophylaxis in children with newly diagnosed acute myeloid leukaemia. The Journal of antimicrobial chemotherapy 67.9 6 [Clinical characteristics, diagnosis, and treatment of 40 cases of venous thrombotic disease in children at a single center]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 63.64 7 Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell-State Plasticity in the CFTR Modulator Era. Cell proliferation 53.2 8 Second Primary Malignancies Among Pediatric and Young Adult Survivors of Differentiated Thyroid Cancer: Real-World Evidence. Thyroid : official journal of the American Thyroid Association 72.6 9 [Clinical study of brentuximab vedotin combined with the ifosfamide and gemcitabine regimen in the treatment of children with relapsed or refractory classic Hodgkin lymphoma]. Zhonghua er ke za zhi = Chinese journal of pediatrics 74.5 10 [Clinical characteristics of regional portal hypertension in children presenting with isolated gastric fundal varices]. Zhonghua er ke za zhi = Chinese journal of pediatrics 58.9 11 The Psychosocial Impact on Families of Paediatric Long-Term Mechanical Circulatory Support Patients During In-Hospital Bridge-to-Transplant: A Qualitative Systematic Review. Journal of clinical nursing 73.5 12 Infantile Central Nervous System Juvenile Xanthogranuloma With Somatic CSF1R Mutation Responsive to Imatinib Monotherapy. Pediatric blood & cancer 63.64 13 Feasibility, Treatment Planning, and Clinical Results of VMAT-Based Total Body Irradiation for Pediatric Patients: Single-Center Experience. Pediatric blood & cancer 65.54 14 MIR17HG Expression Is Transcriptionally Regulated by PAX3::FOXO1 and MYCN and is Necessary for Oncogenic Activity in Fusion-Positive Rhabdomyosarcoma. Molecular cancer research : MCR 51.0 15 False-Positive 123I-MIBG Uptake Attributable to Contralateral Erector Spinae Muscle Hypertrophy Following Retroperitoneal Surgery in a Child With Neuroblastoma. Clinical nuclear medicine 35.0 16 Primary cervical multifocal medulloblastoma: a unique case report and review of the literature. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 53.9 17 Challenging the size: ovarian-sparing surgery in borderline huge pediatric ovarian tumors. Pediatric surgery international 61.5 18 Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 64.14 19 Late oral complications and assessment of oral symptoms in childhood and adolescent cancer survivors following head and neck radiotherapy: a cross-sectional study. Oral oncology 70.04 20 The Gabriella Miller Kids First Data Resource for genomic research in pediatric cancer and congenital anomalies. American journal of human genetics 64.0 21 Long-term PM2.5 exposure and leukemia risk from childhood to early adulthood: A nationwide longitudinal cohort study with time-varying exposure analysis. Environmental research 57.5 22 Isolated deep orbital haemangioma in an infant presenting to the emergency department with right-sided proptosis. BMJ case reports 54.0 23 Paediatric-type diffuse low-grade gliomas: A pictorial review. The neuroradiology journal 58.4 24 Langerhans Cell Histiocytosis in Adults: A Canadian Multicenter Case Series. Hematological oncology 76.9 25 DSCAM-AS1 Facilitates Osteosarcoma Progression via Regulating miR-211-5p/PDCD6 Axis. Drug development research 53.4 26 [Evolution of Glioma Diagnosis: The WHO 2021 Classification and Beyond]. No shinkei geka. Neurological surgery 56.0 27 [Recent Advances in the Classification and Treatment of Pediatric Gliomas]. No shinkei geka. Neurological surgery 63.24 28 [Molecular Classification and Treatment of Medulloblastoma: An Update]. No shinkei geka. Neurological surgery 67.04 29 [Treatment of CNS Germ Cell Tumors]. No shinkei geka. Neurological surgery 73.04 30 Ovarian gonadotoxicity and gonadoprotection: a narrative review. Reproductive biomedicine online 65.62 31 Robotic Pancreaticoduodenectomy in Pediatric Patients: First Two Reported Cases in the United States. Journal of laparoendoscopic & advanced surgical techniques. Part A 47.5 32 Staged Reconstruction of Distal Femoral Osteosarcoma in a 10-year-old Girl using a Hybrid Endoprosthesis-Motorised Lengthening Nail Construct: A Case Report. Strategies in trauma and limb reconstruction 64.60
PATIENT-FRIENDLY SUMMARY

The prognostic implications of CDKN2A/2B deletion in childhood acute lymphoblastic leukemia: a systematic review and meta-analysis.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic