Cancer Predisposition Syndromes Associated with Most Common Pediatric Solid Tumors.
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In the pediatric setting, cancer predisposition syndromes account for about 8% to 20% of all cancer diagnoses, and these numbers can be higher depending on the tumor type. In this study, we describe a selection of the most common cancer predisposition syndromes related to solid tumors in the pediatric population, which were included in the first edition of the World Health Organization Classification of Tumours: Paediatric Tumours. Certain tumors are so closely linked to a particular syndrome that their diagnosis should prompt a referral to genetics or cancer genetics providers for counseling and follow-up.