Clinical Characteristics and Prognostic Factors of 199 Salivary Acinic Cell Carcinoma.
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OBJECTS: This retrospective study aimed to investigate the clinical characteristics and prognostic features of acinic cell carcinoma (AciCC) of the salivary gland. METHODS: One Hundred Ninety-nine cases of AciCC were retrospectively reviewed. Clinical characteristics and outcomes were systematically collected. Recurrence-free survival, metastases-free survival, and overall survival of patients with different clinical variables were compared using the Kaplan-Meier method and Cox univariate regression. RESULTS: A total of 199 patients were included (70 men, 129 women; mean age, 44.57 years). The parotid gland was most frequently affected (75.0%), and the majority of patients were asymptomatic (71.36%). Most patients underwent surgical treatment. Follow-up data were available for 155 patients, with a mean duration of 78.42 months. Local recurrence occurred in 11.6% of these patients, regional metastases in 6.5%, and distant metastases in 5.2%. Of the 10 patients with metastases, 4 died of AciCC. Poorer survival was significantly associated with age > 40 years, perineural invasion, neck dissection, and advanced stage (III/IV). Recurrence and metastases were strongly associated with AciCC-related mortality. CONCLUSIONS: Regular follow-up and careful lymph node assessment are critical for patients over 40 years, those with perineural invasion, advanced-stage disease, recurrence, or metastases, as these factors are linked to poorer outcomes in AciCCs.