← Back to all signals
RESEARCH PAPER ANALYSIS

Germline polymorphisms of the NOD2 pathway may predict the effectiveness of radioiodine in differentiated thyroid cancer treatment.

AI interpretation is pending for this paper.

Open original publication →
PMID38755492
JournalJournal of endocrinological investigation
Publication Date2024-05-16
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

PURPOSE: Differentiated thyroid cancer (DTC) presents a complex clinical challenge, especially in patients with distant metastases and resistance to standard treatments. This study aimed to investigate the influence of specific genes and their germline single nucleotide polymorphisms (SNPs) linked to both inflammatory processes and other neoplasms on the clinical and pathological characteristics of DTC, particularly their potential impact on radioiodine (RAI) treatment efficacy. METHODS: This retrospective analysis involved a cohort of 646 patients diagnosed with DTC after thyroidectomy. Study covering 1998-2014, updated in 2023, included 567 women and 79 men (median age: 49; range: 7-83). SNP selection targeted functional significance, while mutational status was assessed by pyrosequencing for comprehensive characterization. Patient genetic profiles were assessed for associations with disease characteristics, RAI response, and cancer pathology. RESULTS: Significant correlations emerged between certain SNPs and DTC features. Notably, the NOD2 c.802 T > C variant (rs2066842) was identified as a marker distinguishing between papillary thyroid cancer (PTC) and follicular thyroid cancer (FTC). Moreover, the c.802 T allele was associated with an enhanced response to RAI treatment, indicating a more substantial decrease in posttreatment stimulated thyroglobulin (sTg) concentrations. The NFKB1A allele c.126A (rs696) exhibited connections with lower FTC stages and a reduced probability of multifocality. CONCLUSION: This study explored the molecular mechanisms of particular SNPs, highlighting the role of NOD2 in innate immunity and the stress response, and its potential impact on RAI efficacy. This research underscores the clinical promise of SNP analysis and contributes to personalized treatment strategies for DTC, emphasizing the relevance of genetic factors in cancer progression and treatment outcomes.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Nuclear export inhibition activates TP53 pathways and is a potent therapeutic strategy in atypical teratoid rhabdoid tumors. Neuro-oncology advances 56.94 2 Delayed Detection of Bilateral High-Frequency Sensorineural Hearing Loss Following Childhood Cisplatin Therapy: A Case Report. The journal of international advanced otology 59.94 3 Conservative Management of a Primary Mandibular Second Molar With Dentoalveolar Abscess in a Four-Year-Old Child With Acute Lymphoblastic Leukemia: A Case Report. Cureus 54.3 4 Machine Learning Comparison and Combined Model Optimization Based on DCE-MRI Radiomics for Preoperative Assessment of Lymphovascular Invasion in Breast Cancer: A Multicenter Study. Cancer reports (Hoboken, N.J.) 65.9 5 Pediatric ALK-Negative Anaplastic Large Cell Lymphoma With Recurrent Cutaneous Relapses: Diagnostic Challenges. Pediatric dermatology 61.62 6 A safety review of jak inhibitors for managing alopecia areata. Expert opinion on drug safety 74.06 7 Support for Disclosure of Hereditary Tumor Risk to Children and Adolescents: A Scoping Review. Japan journal of nursing science : JJNS 78.4 8 Late Ischemic Cholangiopathy After Liver Transplantation From a Deceased Donor With Situs Inversus Totalis: A Case Report. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 47.5 9 Lived experiences of parenting-related distress in mothers with gynecological cancer: a descriptive phenomenological study. BMC women's health 58.4 10 Vancomycin Taper-and-Pulse Therapy for Recurrent Clostridioides difficile Infection in Pediatric Acute Lymphoblastic Leukemia Patients Treated With Blinatumomab and Chemotherapy: A Report of Three Cases. Cureus 62.34 11 Percutaneous calcium phosphate cement injection for unicameral bone cysts: mid- to long-term clinical and radiographic outcomes. Frontiers in surgery 63.9 12 Radiographic evidence of thymic involution in hepatocellular carcinoma: a propensity score-matched study in viral cirrhosis. Frontiers in immunology 62.5 13 Case Report: Activated phosphoinositide 3-kinase δ syndrome mimicking Hyper-IgM syndrome: early hepatosplenomegaly as a key diagnostic clue. Frontiers in immunology 56.6 14 Herpes zoster frequency and severity in immunocompromised pediatric populations: a structured narrative review. Frontiers in pediatrics 59.0 15 Recognition and management of early complications in CAR-T cell therapy and virus-specific T-lymphocyte therapy: a practical clinical reference. Frontiers in immunology 75.5 16 Gastric dysbiosis and more severe histological gastritis in symptomatic Helicobacter pylori-infected children and adolescents without ulcers: time to rethink early eradication? Frontiers in microbiology 58.4 17 Surgical management and molecular diagnosis of pediatric cystic nephroma: a single-center case series with implications for DICER1 syndrome surveillance. Translational andrology and urology 56.9 18 Infantile Osteopetrosis with a CLCN7 Variant: An Educational Case Highlighting Integrated Diagnosis and Variant Interpretation. EJIFCC 56.0 19 Plexiform neurofibroma of the scrotum in a 16-year-old male: A case report. Urology case reports 45.5 20 Advanced Imaging Techniques for Early in-Vivo Discrimination of Fibrofolliculomas in Birt-Hogg-Dubé Syndrome. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 57.5 21 Health Behaviors in Adolescent and Young Adult (AYA) Childhood Cancer Survivors: Prevalence, Determinants, and Comparison With Population Controls. Cancer medicine 66.9 22 Mechanism of Gu-Ben-Hua-Shi (AESS) Formula Regulating Autophagy Through Hippo-YAP Pathway in Restoring the Skin Barrier in Atopic Dermatitis. Journal of cellular and molecular medicine 76.35 23 Mapping Psychosocial Determinants for Cancer Onset: An Umbrella Review. Psycho-oncology 74.9 24 Early-onset colorectal cancer burden attributable to early-life obesity from 2000 to 2020 with projections to 2040. Cancer epidemiology 57.5 25 The effect of unique molecular identifier family size using tumor-informed circulating tumor-DNA analysis in childhood cancers. The Journal of molecular diagnostics : JMD 59.6 26 GATA3-driven CDC20 activation facilitates tumor growth and metastasis through suppressing Bax/Bcl-2 ratio and boosting EMT process in neuroblastoma. The Journal of biological chemistry 60.6 27 [Masked pediatric pathological femoral fracture : Case report of a sarcoma-associated femoral fracture after adequate trauma]. Unfallchirurgie (Heidelberg, Germany) 49.9 28 Antiviral therapies are associated with reduced mortality but under-utilized in patients with viral hepatocellular carcinoma: a multinational REAL-HCC study. Hepatology international 61.1 29 Privacy-Preserving Linkage of Distributed Biological, Clinical, and Imaging Data Supporting Artificial Intelligence in Pediatric Oncology. Methods of information in medicine 71.9 30 Risk and benefit for targeted therapy agents in paediatric phase I trials in oncology: a systematic review and meta-analysis protocol. BMJ open 83.72 31 Testicular Tissue Cryopreservation in Prepubertal Boys: Current Advances, Clinical Feasibility, and Future Directions-A Comprehensive Literature Review. Andrology 63.6 32 Opioid limiting law and opioid prescriptions among Medicaid-enrolled survivors of childhood cancer. Journal of the National Cancer Institute 57.5
PATIENT-FRIENDLY SUMMARY

Germline polymorphisms of the NOD2 pathway may predict the effectiveness of radioiodine in differentiated thyroid cancer treatment.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic