Case report of a 6-year-old with a novel homozygous HPD variant causing tyrosinemia type III coexisting with Wolff–Parkinson–White syndrome, presenting with ketotic hypoglycemia and neurodevelopmental issues.

Single-nucleus RNA-seq of striatal tissue from MSA, PD, and controls shows PD microglia with MHC-II–linked proinflammatory signatures and more homeostatic astrocytes, whereas MSA features microglia in an immune-tolerant/exhausted state, reactive astrocytes, compromised oligodendrocyte signaling,…

Large-scale CSF and plasma proteomics across AD, PD, DLB, and FTD (n≈2.7–3.0k) reveals shared immune dysregulation and disease-specific pathway changes, with PD showing ATF4/PERK (ER stress) signaling alterations and high-performing CSF/plasma diagnostic models.

Introduces a Comparator-Based Dynamical Timing (CDT) model that attributes subjective time distortions to altered cerebellar scaling of time (gain κ) and situates cerebellar comparator interactions with cortex and basal ganglia to explain timing abnormalities across psychiatric and…

In MPTP mice, transcranial magneto-acoustic stimulation (TMAS) reduced presynaptic glutamate release, improved NMDAR- and D1 receptor–dependent corticostriatal synaptic transmission and plasticity, normalized spine subtype distribution, decreased α-synuclein and dopaminergic neuron loss, and…

Introduces PMGCN, a percolation-based method to find parsimonious multi-disease gene co-expression biomarkers from bulk transcriptomes, validated mainly on ulcerative colitis and other inflammatory diseases but not producing PD-specific biomarkers.

This in vivo mouse study reports that systemic retinol administration promotes neural stem cell self-renewal and oriented development while downregulating certain retinoic acid receptor genes in the brain.

Qualitative study of 17 interviews plus cohort analysis identifies five coping styles (taking action, distancing, mental solutions, social support, coming to terms) and 28 strategies in young-onset Parkinson’s disease, with greater use of ‘distancing’ linked to higher psychological distress.

The study introduces N,P-co-doped fluorescent carbon dot–enhanced microdialysis to monitor hypochlorite (ClO−) in real time in the striatum and shows sustained ClO− elevation for up to 11 hours after MPTP treatment, concurrent with microglial IBA1 upregulation and increased IL-1β, IL-6, and TNF-α.

Retrospective pharmacovigilance and literature review identified 54 cases of bilateral corneal edema associated with chronic amantadine use (median dose 200 mg, median onset 12 months), prompting label changes.

This multimodal MRI study reports disease-specific glymphatic dysfunction and free-water patterns—cortical/midline in PD and cerebellar in MSA—with glymphatic–FW coupling mediating symptoms in PD but not MSA, and an integrated biomarker panel yielding AUC=0.994 for differential diagnosis.

This review synthesizes in vitro, animal, and clinical evidence that copper dyshomeostasis promotes α-synuclein misfolding and impairs ubiquitin–proteasome and autophagy–lysosome clearance pathways, proposing selective modulation of intracellular copper pools as a potential therapeutic strategy for…

This review advocates shifting PD to a biologically defined disorder, emphasizing molecular imaging (dopaminergic imaging, [18F]FDG PET, cardiac [123I]MIBG), the promise of α‑synuclein PET, seed amplification assays, and genetic stratification to create biomarker-driven classification systems.

This review synthesizes human and animal data on how STN-DBS affects cognition, identifies patient-, lead-, and parameter-dependent sources of variability, and evaluates emerging closed-loop/adaptive DBS approaches and biomarker strategies to preserve cognitive function while maintaining motor…

This review summarizes how alternative splicing contributes to neurodegenerative diseases, highlights dysregulated splicing of SNCA and PARK2 in Parkinson's disease, and surveys emerging splicing-based therapies and biomarkers.

Introduces ProtoSleepNet, an interpretable prototype-based multimodal sleep staging model that achieves high accuracy and produces prototype-grams which discriminate Parkinson's and Alzheimer's patients from controls by capturing disease-linked sleep microstructure alterations.

Longitudinal analysis of 337 PPMI patients shows that depression and cognitive impairment independently and jointly mediate the effect of REM sleep behavior disorder on activities of daily living in PD, with mediating effects increasing over time.

This review synthesizes recent advances in PD pathophysiology, patient-derived iPSC models, 3D bioprinting, animal models, imaging, and biomarker discovery and advocates cross-platform integration to improve translational relevance.

In a 73,281-person Finnish cohort with ~25 years mean follow-up, self-reported frequent insomnia and an insomnia polygenic risk score were modestly associated with higher incident Parkinson's disease risk, whereas sleep duration was not.

SPECT 123I-ioflupane imaging in four CSF1R mutation carriers found preserved presynaptic dopamine transporter binding in three patients with parkinsonism, indicating motor deficits may arise from white-matter/ connectivity disruption rather than primary nigrostriatal degeneration.