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RESEARCH PAPER ANALYSIS

From accepting to distancing as different coping strategies in persons with young onset Parkinson's disease.

Qualitative study of 17 interviews plus cohort analysis identifies five coping styles (taking action, distancing, mental solutions, social support, coming to terms) and 28 strategies in young-onset Parkinson’s disease, with greater use of ‘distancing’ linked to higher psychological distress.

PMID41935102
JournalNPJ Parkinson's disease
Publication Date2026-04-04
Ingested2026-04-28 08:58 PM
EXECUTIVE SUMMARY

What the AI sees

Qualitative study of 17 interviews plus cohort analysis identifies five coping styles (taking action, distancing, mental solutions, social support, coming to terms) and 28 strategies in young-onset Parkinson’s disease, with greater use of ‘distancing’ linked to higher psychological distress.

WHY IT MATTERS

Research significance

Provides insight into psychosocial coping patterns that could guide supportive behavioral interventions and trial endpoints but has limited direct relevance to molecular mechanisms or drug discovery.

ABSTRACT

Source abstract

People with young onset Parkinson's disease (YOPD) encounter unique challenges. Coping is therefore vitally important to effectively manage stressors. We thematically analyzed 17 semi-structured interviews regarding coping strategies. In cohort data (YOPD n = 74, late onset PD n = 214), we analyzed the frequency of coping styles. Most people with YOPD used a mixture of five styles: (1) taking action, (2) distancing, (3) mental solutions, (4) social support, and (5) coming to terms. Within these styles, we identified 28 different strategies, and described how participants apply these in a flexible manner. We found an association between a higher use of coping through distancing and psychological distress and used qualitative interview data to explore a possible bidirectional relationship. This study offers a first indication of how people cope with YOPD. The observed association between distancing and distress should be studied further. If found to be causal, coping flexibility might become a potential interventional target.

SUPPORTING PAPER SET

32 more papers to review

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Cell death discovery 82.0 24 Brain-gut-microbiota axis: a review on the bidirectional regulatory mechanisms between gut microbiota and brain and their disease interactions. Frontiers in microbiology 74.0 25 Long non-coding RNAs in neurodegenerative diseases - Molecular mechanisms, liquid biopsy biomarkers, and therapeutic targets: A review. Biomolecules & biomedicine 84.0 26 Neurosyphilis and Parkinsonism: Overlapping Pathophysiology and Emerging Therapeutic Insights. Current neurovascular research 76.0 27 Molecular biochemistry of soluble epoxide hydrolase in lipid mediator pathways and neuroinflammatory responses. The Journal of steroid biochemistry and molecular biology 82.0 28 Multifaceted role of CNPY2 beyond ER stress: Disease implications and therapeutic potential. Cell stress 83.3 29 Neuroprotective Role of Exercise-based Physiotherapy Combined with Pharmacological Agents in Parkinson's Disease. Central nervous system agents in medicinal chemistry 64.0 30 Distinct metabolomic and proteomic signatures in Parkinson's disease patients with REM sleep behavior disorder. Signal transduction and targeted therapy 84.0 31 HMGB1-mediated neuroinflammation: molecular mechanisms and emerging therapeutic approaches. Inflammopharmacology 78.0 32 Beyond acid-base dyshomeostasis: Dynamic instability of neuronal lysosomal pH as a pathogenic mechanism and therapeutic target in neurological diseases. Biochemical pharmacology 88.0
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