Development of the Children's Oncology Group long-term follow-up guideline for cancer genetics evaluation in childhood cancer survivors.
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Up to 12% of childhood cancer survivors have an underlying cancer predisposition syndrome (CPS). As a result, these childhood cancer survivors are at increased risk for developing and succumbing to subsequent malignant neoplasms. Identifying childhood cancer survivors with CPS is essential to improving overall outcomes by informing tailored approaches to cancer screening, treatment, and, for some, risk-reducing interventions. Despite these potential benefits, it is often unclear which childhood cancer survivors warrant referral for genetic counselling and germline genetic testing. Using an evidence-based approach, a standardised guideline for referral for cancer genetics evaluation of childhood cancer survivors at high risk of having a CPS was developed and incorporated into the Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancers. This Policy Review details the importance, development, and anticipated impact of this new guideline. Raising awareness of this guideline is crucial to enhancing the integration of genetics into survivorship care and improving health outcomes for childhood cancer survivors with CPS.