← Back to all signals
RESEARCH PAPER ANALYSIS

Mechanism of Gu-Ben-Hua-Shi (AESS) Formula Regulating Autophagy Through Hippo-YAP Pathway in Restoring the Skin Barrier in Atopic Dermatitis.

AI interpretation is pending for this paper.

Open original publication →
PMID42730570
JournalJournal of cellular and molecular medicine
Publication Date2026-09-01
Ingested2026-09-13 09:15 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by skin barrier dysfunction and immune balance disorders. Currently, drugs for repairing the skin barrier in AD are limited. The gu-ben-hua-shi formula (AESS) has been shown to regulate Th1/Th2/Th17/Treg imbalance with good clinical effect. However, its effects on regulating autophagy, repairing the skin barrier, and interacting with Yes-associated protein (YAP) remain unknown. To elucidate the therapeutic effects of AESS on AD and to investigate its mechanism of restoring skin barrier function through the Hippo-YAP pathway. We conducted a single-arm observational study to evaluate the clinical efficacy of the AESS in patients with AD. Network pharmacology was used to predict the potential therapeutic targets and mechanisms. AD mouse models were established by house dust mite stimulation in Nishiki-nezumi Cinnamon/Nagoya mice, and the effects on autophagy and the skin barrier were measured using western blotting, immunofluorescence, mRFP-GFP-LC3 tandem fluorescence assay, and transmission electron microscopy. The effects of AESS serum on an AD-like inflammatory cell model were detected in HaCaT cells stimulated with interferon-γ (IFN-γ)/tumour necrosis factor-α (TNF-α). Activity of the Hippo-YAP signalling pathway was also investigated after YAP knockdown. AESS improved skin rash and barrier function, reduced eosinophil counts, and increased Th1/Th2 and Treg/Th17 ratios in patients with AD. AESS increased autophagy, improved skin barrier function, and inhibited Hippo-YAP signalling pathway activity. YAP knockdown reduces these therapeutic effects. Besides regulating immune imbalance, AESS increases keratinocyte autophagy levels, thereby restoring skin barrier function in AD through the Hippo-YAP signalling pathway. Trial Registration: The Chinese clinical trial registration website: ITMCTR202500042.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Late Ischemic Cholangiopathy After Liver Transplantation From a Deceased Donor With Situs Inversus Totalis: A Case Report. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 47.5 2 Lived experiences of parenting-related distress in mothers with gynecological cancer: a descriptive phenomenological study. BMC women's health 58.4 3 Vancomycin Taper-and-Pulse Therapy for Recurrent Clostridioides difficile Infection in Pediatric Acute Lymphoblastic Leukemia Patients Treated With Blinatumomab and Chemotherapy: A Report of Three Cases. Cureus 62.34 4 Percutaneous calcium phosphate cement injection for unicameral bone cysts: mid- to long-term clinical and radiographic outcomes. Frontiers in surgery 63.9 5 Radiographic evidence of thymic involution in hepatocellular carcinoma: a propensity score-matched study in viral cirrhosis. Frontiers in immunology 62.5 6 Case Report: Activated phosphoinositide 3-kinase δ syndrome mimicking Hyper-IgM syndrome: early hepatosplenomegaly as a key diagnostic clue. Frontiers in immunology 56.6 7 Herpes zoster frequency and severity in immunocompromised pediatric populations: a structured narrative review. Frontiers in pediatrics 59.0 8 Recognition and management of early complications in CAR-T cell therapy and virus-specific T-lymphocyte therapy: a practical clinical reference. Frontiers in immunology 75.5 9 Gastric dysbiosis and more severe histological gastritis in symptomatic Helicobacter pylori-infected children and adolescents without ulcers: time to rethink early eradication? Frontiers in microbiology 58.4 10 Surgical management and molecular diagnosis of pediatric cystic nephroma: a single-center case series with implications for DICER1 syndrome surveillance. Translational andrology and urology 56.9 11 Infantile Osteopetrosis with a CLCN7 Variant: An Educational Case Highlighting Integrated Diagnosis and Variant Interpretation. EJIFCC 56.0 12 Plexiform neurofibroma of the scrotum in a 16-year-old male: A case report. Urology case reports 45.5 13 Advanced Imaging Techniques for Early in-Vivo Discrimination of Fibrofolliculomas in Birt-Hogg-Dubé Syndrome. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 57.5 14 Health Behaviors in Adolescent and Young Adult (AYA) Childhood Cancer Survivors: Prevalence, Determinants, and Comparison With Population Controls. Cancer medicine 66.9 15 Mapping Psychosocial Determinants for Cancer Onset: An Umbrella Review. Psycho-oncology 74.9 16 Early-onset colorectal cancer burden attributable to early-life obesity from 2000 to 2020 with projections to 2040. Cancer epidemiology 57.5 17 The effect of unique molecular identifier family size using tumor-informed circulating tumor-DNA analysis in childhood cancers. The Journal of molecular diagnostics : JMD 59.6 18 GATA3-driven CDC20 activation facilitates tumor growth and metastasis through suppressing Bax/Bcl-2 ratio and boosting EMT process in neuroblastoma. The Journal of biological chemistry 60.6 19 [Masked pediatric pathological femoral fracture : Case report of a sarcoma-associated femoral fracture after adequate trauma]. Unfallchirurgie (Heidelberg, Germany) 49.9 20 Antiviral therapies are associated with reduced mortality but under-utilized in patients with viral hepatocellular carcinoma: a multinational REAL-HCC study. Hepatology international 61.1 21 Privacy-Preserving Linkage of Distributed Biological, Clinical, and Imaging Data Supporting Artificial Intelligence in Pediatric Oncology. Methods of information in medicine 71.9 22 Risk and benefit for targeted therapy agents in paediatric phase I trials in oncology: a systematic review and meta-analysis protocol. BMJ open 83.72 23 Testicular Tissue Cryopreservation in Prepubertal Boys: Current Advances, Clinical Feasibility, and Future Directions-A Comprehensive Literature Review. Andrology 63.6 24 Opioid limiting law and opioid prescriptions among Medicaid-enrolled survivors of childhood cancer. Journal of the National Cancer Institute 57.5 25 The efficacy of 1064-nm Nd: YAG picosecond laser for Becker's nevus: a retrospective analysis of 49 cases. Lasers in medical science 61.6 26 Recognizing genetic association between Lhermitte-Duclos Disease and Autism Spectrum Disorder in PTEN-related patients: a case report and literature comprehension. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 49.0 27 Incidence and survival of pediatric low-grade gliomas in Switzerland. World journal of pediatrics : WJP 73.92 28 Unmasking phenotypic heterogeneity and extracellular matrix architecture in neuroblastoma through orthotopic xenograft modeling. Translational oncology 53.4 29 Global burden and inequalities of Hodgkin and non-Hodgkin lymphoma among children aged 0-14 years, 1990-2021: a GBD 2021 analysis with forecasts to 2035. Jornal de pediatria 59.9 30 From Kitchen to Clinic: Study protocol for a family-centered, food-as-medicine approach using medically tailored meals and caregiver coaching in pediatric oncology care. Contemporary clinical trials communications 64.4 31 Obesity and Cardiovascular Disease: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2026. Obesity pillars 61.9 32 Effects of eHealth interventions on depression, anxiety, quality of life, and post-traumatic stress symptoms among parents of children with cancer: A meta-analysis of randomized controlled trials. Asia-Pacific journal of oncology nursing 75.7
PATIENT-FRIENDLY SUMMARY

Mechanism of Gu-Ben-Hua-Shi (AESS) Formula Regulating Autophagy Through Hippo-YAP Pathway in Restoring the Skin Barrier in Atopic Dermatitis.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic