← Back to all signals
RESEARCH PAPER ANALYSIS

Large Estrogen and Cortisol Co-Secreting Adrenocortical Tumor in a 17-year-old Female: Case Report and Literature Review.

AI interpretation is pending for this paper.

Open original publication →
PMID42700419
JournalHormone research in paediatrics
Publication Date2026-09-05
Ingested2026-09-06 09:15 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

INTRODUCTION: Adrenocortical tumors (ACTs) are rare pediatric tumors which include both benign adrenocortical adenomas (ACAs) and malignant adrenocortical carcinomas (ACCs). The most common presentations of an ACT in children are virilization and/or Cushing's syndrome resulting from tumoral secretion of androgens and cortisol, respectively. Adrenocortical tumors that express high levels of estrogen are extremely rare, and adrenal tumors that co-secrete more than one class of adrenal hormones raise concern for malignancy. CASE PRESENTATION: We present a case of a 17-year-old female presenting with weight gain, secondary amenorrhea, and acute abdominal pain. She was found to have a large (9.4 cm) right adrenal tumor co-secreting both cortisol and estrogen, which was successfully surgically removed by minimally-invasive laparoscopy. Her perioperative course was complicated by severe refractory hypertension requiring multiple antihypertensive medications, and venous thromboses associated with hypercoagulability. Genetic testing revealed no germline driver mutation. Classification of the adrenal tumor as either benign or malignant was discordant when determined by the adult Weiss vs. the pediatric AFIP/Wieneke criteria in this older adolescent. CONCLUSION: This prismatic case of a rare estrogen-cortisol secreting tumor raises discussion regarding the complexities in the clinical presentation and uncertainties in prognosis of adrenal tumors in adolescents. A literature review showcases 19 case reports published between 1948-2025 of estrogen-secreting pediatric ACTs highlighting their rare prevalence. This case stresses the need for a multidisciplinary approach to diagnosis, treatment, and long-term management of this entity in children and adolescents.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 The Hidden Culprit - Caroli Disease Presenting as Recurrent Liver Abscesses in a 5-year-old Boy. International journal of applied & basic medical research 59.6 2 Anti-N-methyl-D-Aspartate Receptor Autoimmune Encephalitis Due to Ovarian Teratoma in a 17-Year-Old Young Woman: Case Report and Review of the Literature. EJIFCC 51.5 3 The Case of Negative Low Density Lipoprotein Cholesterol. EJIFCC 56.0 4 Pediatric venous thromboembolism: an illustrated review. Research and practice in thrombosis and haemostasis 57.6 5 Endoscopic third ventriculostomy for obstructive hydrocephalus combined with biopsy for tumors located in the tectum/posterior third ventricle using a single burr hole technique guided by electromagnetic navigation in pediatric neurosurgery. Clinical neurology and neurosurgery 62.9 6 Paratesticular myofibroblastic lesion in a prepubertal child: a case report of a rare spindle cell tumor with testis-sparing management. Frontiers in urology 47.5 7 Lived experiences of sexual wellbeing and psychosexual needs among adolescents and young adults with sarcoma: a qualitative study. Frontiers in psychology 57.5 8 Prognostic impact of CD123 overexpression on the outcome of pediatric acute myeloid leukemia. Frontiers in oncology 76.4 9 A rare case of multi-segmental lumbar intradural ependymoma: clinical presentation and surgical management: a case report. Frontiers in oncology 58.2 10 Willingness to receive cross-border human papillomavirus vaccination among Chinese male university students: a cross-sectional study with statistical indirect-association analysis. Frontiers in public health 70.0 11 The lived experience of resilience in families of children with cancer: a meta-aggregative synthesis of qualitative studies. Frontiers in psychiatry 73.5 12 Pediatric Leydig Cell Tumor: Biochemical Mimicry of Adrenal Disease and a Cause of Central Precocious Puberty. Acta medica portuguesa 47.5 13 Patterns of Cancer Frequency in Balochistan: Regional Perspectives and Implications for Cancer Control. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 64.5 14 Immunohistochemical Expression of Fascin-1 in Colorectal Carcinoma and Its Association with Pathological Grade and Stage. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 62.0 15 Sinonasal osteosarcoma of the ethmoid bone with decade-later recurrence presenting as early orbital apex syndrome: an 18-year case report. International journal of surgery case reports 55.9 16 Renal cell carcinoma in a child presenting with chronic gross hematuria: A rare case report with diagnostic and surgical insights. Urology case reports 52.3 17 Nasopharyngeal carcinoma with osseous metastases in an 8-year-old girl: a case report. International journal of surgery case reports 57.3 18 Childhood cancer survivors in India: gender gap in long-term survivorship care. The Lancet regional health. Southeast Asia 47.5 19 Extraneural cysticercosis mimicking soft-tissue tumors: a case report from a low-resource setting. International journal of surgery case reports 53.0 20 Delayed Diagnosis of Tuberous Sclerosis Complex Presenting as Abnormal Uterine Bleeding: A Case Report and Literature Review. Clinical case reports 47.5 21 Comparison of diagnostic criteria for disseminated intravascular coagulation in critically ill children. Pediatric research 57.5 22 Age as a core disease modifier: Distinct clinical, molecular and prognostic landscapes of essential thrombocythaemia in adolescents and young adults. British journal of haematology 69.7 23 Global burden of thyroid cancer among women aged 15 to 49 years, 1990-2021: An ecological analysis of spatiotemporal trends, socioeconomic inequalities, and projections to 2040. Medicine 59.9 24 Global trends in gastric cancer burden among adolescents and young adults: A population-based observational study using GBD 2021 data. Medicine 59.0 25 Pathological lead points in pediatric secondary intussusception: A single-center retrospective observational study of five common etiologies. Medicine 65.5 26 Comparative outcomes of phenol therapy and Karydakis flap in pilonidal sinus disease: A retrospective cohort study with 1-year follow-up. Medicine 72.64 27 Non-ossifying fibroma of the proximal tibia mimicking chronic osteomyelitis in a child. BMJ case reports 56.4 28 Optimising Human Papillomavirus Vaccination Strategies for Faster Cervical Cancer Elimination. Acta paediatrica (Oslo, Norway : 1992) 59.2 29 Fighting a Dual Battle: The Harrowing Course of B/T Lineage Mixed Phenotype Acute Leukemia in a Child. Indian journal of pediatrics 28.5 30 INTRATHYROIDAL ECTOPIC THYMUS: THE TRICK OF THE TRADE. Hormone research in paediatrics 60.5 31 Dinutuximab beta with TEMIRI chemotherapy in relapsed/refractory neuroblastoma: Real-world insights into the open question of GD2 expression. Translational oncology 75.5 32 Physiologically based pharmacokinetic modeling for methotrexate in cerebrospinal fluid in humans. Journal of pharmaceutical sciences 62.0
PATIENT-FRIENDLY SUMMARY

Large Estrogen and Cortisol Co-Secreting Adrenocortical Tumor in a 17-year-old Female: Case Report and Literature Review.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic