Surgical Management of Metastatic Pediatric Solid Tumors: Histology-specific Strategies and Multidisciplinary Approaches.
This article reviews histology-specific indications and multidisciplinary integration of metastasectomy for several metastatic pediatric solid tumors, including management of pulmonary and extrapulmonary disease while considering function and late morbidity.
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This article reviews histology-specific indications and multidisciplinary integration of metastasectomy for several metastatic pediatric solid tumors, including management of pulmonary and extrapulmonary disease while considering function and late morbidity.
Research significance
The supplied record supports the clinical premise that metastasectomy should be individualized by histology, treatment response, metastatic site, and systemic treatment context; it can only be inferred—not established from reported comparative outcomes—that this tailoring may improve tumor control while limiting functional loss and late morbidity.
Source abstract
Metastatic pediatric solid tumors require tailored surgical approaches guided by tumor histology, treatment response, and multidisciplinary collaboration. This article reviews current strategies for surgical management of metastases across common pediatric cancers, including osteosarcoma, Ewing sarcoma, Wilms tumor, rhabdomyosarcoma, hepatoblastoma, and nonrhabdomyosarcoma soft tissue sarcomas. Emphasis is placed on indications for metastasectomy and the integration of surgery with systemic therapies. Special considerations for extrapulmonary metastases including liver, lymph node, bone, and brain involvement are also addressed. The article underscores the importance of multidisciplinary care to balance aggressive tumor control with preservation of long-term function and reduction of late treatment-related morbidity.