Primary Bone Tumors: Osteosarcoma and Ewing Sarcoma.
This comprehensive review summarizes recent advances in osteosarcoma and Ewing sarcoma management, including technology-assisted surgery, biomaterials and custom-growing implants, emerging targeted therapies, and proton or carbon-ion radiotherapy.
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This comprehensive review summarizes recent advances in osteosarcoma and Ewing sarcoma management, including technology-assisted surgery, biomaterials and custom-growing implants, emerging targeted therapies, and proton or carbon-ion radiotherapy.
Research significance
The record reports that evolving surgical technologies and newer radiation modalities may improve management and that targeted therapies could improve survivorship; it is reasonable to hypothesize that integrating these approaches may enhance tumor control or reduce treatment morbidity, but the supplied abstract provides no specific target, comparative outcome, safety result, or clinical validation.
Source abstract
Substantial recent progress has been made in the management of osteosarcoma and Ewing sarcoma, the most common childhood bone sarcomas. Surgical treatment continues to evolve through navigation, 3D printing, biomaterials, and custom-growing implants. New targeted therapies on the horizon have the potential to achieve a breakthrough improvement in survivorship. Newer radiation modalities, such as proton and carbon-ion radiotherapy, have greater therapeutic potential than conventional photon-beam radiotherapy. This article provides a comprehensive review of common childhood sarcomas and highlights recent advances.