← Back to all signals
RESEARCH PAPER ANALYSIS

Evaluating the impact of virtual oncology financial and legal navigation on cancer-related financial toxicity.

AI interpretation is pending for this paper.

Open original publication →
PMID42636254
JournalJNCI cancer spectrum
Publication Date2026-08-24
Ingested2026-08-25 09:15 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

PURPOSE: To evaluate the impact of a virtual oncology financial and legal navigation (OFLN) intervention on cancer-related financial toxicity (FT) and health-related quality of life (QOL) in pediatric and adolescent and young adult (PAYA) cancer patients and caregivers, as well as assess the intervention's acceptability and feasibility. METHODS: A single-arm trial was conducted in a PAYA oncology clinic between March 2024 and May 2025. Pre- and post-intervention surveys included the Comprehensive Score for Financial Toxicity (COST), Patient-Reported Outcomes Measurement Information System global health, anxiety and depression scales, National Comprehensive Cancer Network's Distress Thermometer, and intervention acceptability, appropriateness and feasibility of Measures. RESULTS: The majority (36 patients and 88 caregivers) identified as female (73%), non-Hispanic White (85%), rural residents (61%), with incomes above the federal poverty level (71%). Participants reported moderate levels of FT at baseline with mean COST of 20.9 (SD = 11.14) for patients and 19.3 (SD = 10.12) for caregivers and high levels of anxiety, depression, and distress. Among caregivers, there was a significant (p = 0.01) post-intervention increase in COST (indicating decreased FT). Almost all patients reported decreases in subjective stress and anxiety (94%) and feeling better prepared to navigate financial/legal issues. Participants rated the intervention highly across implementation outcomes of acceptability (76%), appropriateness (76%), and feasibility (75%), which was also supported by 89% enrollment and 95% retention rates. CONCLUSION: Findings demonstrate that virtual OFLN has the potential to increase access to supportive care services especially in rural communities. Additional research supporting scalability and uptake for widespread implementation is needed.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Biomarker-Negative and MIBG-Negative Neuroblastoma Presenting as an Indeterminate Retroperitoneal Mass in a Young Child. Pediatrics international : official journal of the Japan Pediatric Society 29.85 2 Hypophosphatemic rickets in children: current knowledge and a proposal for a diagnostic algorithm. Endokrynologia Polska 58.0 3 Effectiveness of the "Golden Hour" program in preventing sepsis in pediatric patients with acute lymphoblastic leukemia. Boletin medico del Hospital Infantil de Mexico 65.0 4 Clinical validation of the nursing diagnosis of inadequate nutritional intake in children with cancer. International journal of nursing knowledge 67.6 5 Exploratory Analysis of the Inhibitory Effects of Propranolol on NLRP3 and Pyrin Inflammasomes. ACR open rheumatology 56.76 6 First-In-Human Evaluation of the Pharmacokinetics, Pharmacodynamics, and Safety of Tilpisertib Fosmecarbil (GS-5290), an Oral Prodrug of a Tumor Progression Locus 2 Inhibitor in Healthy Participants. Journal of clinical pharmacology 84.72 7 Dyadic Latent Profiles of Sexual and Reproductive Distress in Young Adult Cancer Survivors and Their Partners: A Cross-Sectional Analysis. Psycho-oncology 61.0 8 Disproportionality analysis of drug-induced myocarditis: Insights from the Food and Drug Administration Adverse Event Reporting System database. The Journal of international medical research 63.68 9 Innovative Insights into Osteosarcoma: Unraveling the Role of LncRNAs, miRNAs, and CircRNAs in Tumorigenesis and Therapeutic Resistance. Current gene therapy 63.84 10 Targeting Metal-Dependent Cell Death in Cancer: From Molecular Circuitry to Biomarker-Guided Precision Combination Therapy. Current cancer drug targets 70.99 11 Long-term outcomes of non-operative compared to operative management of acute uncomplicated appendicitis - a systematic review and meta-analysis. American journal of surgery 72.5 12 What have I missed again: A qualitative study exploring parents of children with cancer's experiences of fear of missing out. Journal of health psychology 54.0 13 Radiographic overestimation of inferior vena cava involvement in pediatric neuroblastoma: a case report. Journal of surgical case reports 55.5 14 Global Burden and Temporal Trends of Brain and Central Nervous System Tumors in Children and Adolescents: A Systematic Analysis for the Global Burden of Disease Study 2021. Cancer innovation 56.0 15 Refractory Hyperammonemic Encephalopathy as a Paraneoplastic Presentation of Fibrolamellar Hepatocellular Carcinoma: A Case Report. The American journal of case reports 53.92 16 Modern management and multidisciplinary care of bladder prostate rhabdomyosarcoma. Current opinion in pediatrics 62.8 17 Improving Dietary Data Quality in Nutrition Studies: Development and Validation of an Explainable, Reproducible, Open Machine Learning-Assisted Framework for Outlier Detection in 24-Hour Recalls. American journal of epidemiology 61.5 18 Genetic Markers of Early Skeletal Muscle Loss in Adolescent and Young Adult Cancer Patients Treated with Anthracyclines. Journal of adolescent and young adult oncology 65.5 19 Seen, Heard, and Still Missing: Understanding Clinical Trial Nonparticipation Among Women of Color. Journal of adolescent and young adult oncology 74.5 20 Correction to "Health-Related Quality of Life in Chinese Children and Adolescents With Cancer: A Systematic Review and Meta-Analysis". International journal of cancer 63.0 21 Evolution of robotic-assisted resection of pediatric neuroblastic tumors: a retrospective analysis. Updates in surgery 61.5 22 Late cardiac effects of anthracycline-based therapy in childhood cancer survivors: a CMR study of cardiac strain and function. Clinical research in cardiology : official journal of the German Cardiac Society 68.34 23 Biological reconstruction in the growing child after tumour resection: long-term outcomes of vascularized fibular epiphyseal transfer. International orthopaedics 57.2 24 Neuroimaging findings of the hypothalamus and pituitary gland in children with growth hormone deficiency: a 25-year single-center retrospective study. Hormones (Athens, Greece) 67.0 25 Ovarian Lymphoma and Bone Metastasis Presenting With Paraparesis in an Adolescent: A Case Report. The American journal of case reports 51.9 26 Pharmacogenetic variants in the molecular characterization initiative: a report from the children's oncology group. Journal of the National Cancer Institute 65.4 27 Impact of Satisfactory Family Coping on the Mental Health of Parents Whose Children Died of Cancer. Journal of pain and symptom management 59.5 28 Surgical approach to solid breast masses in girls. Journal of pediatric and adolescent gynecology 58.4 29 Pediatric and Adolescent Gynecological Tumors and Associated Predisposition Syndromes. Journal of pediatric and adolescent gynecology 56.0 30 Facial nerve schwannoma of the accessory parotid gland region in a child managed through a transoral approach. BMJ case reports 56.0 31 Durvalumab and tremelimumab, with or without lenvatinib, combined with transarterial chemoembolisation in participants with embolisation-eligible hepatocellular carcinoma (EMERALD-3): a global, randomised, open-label, sponsor-blinded, phase 3 study. The Lancet. Oncology 85.2 32 "This Is Loneliness, Helplessness, Desolation…": Exploring the Emotions and Emotion Regulation Experiences of Mothers of Children Diagnosed With Acute Lymphoblastic Leukemia. Cancer nursing 58.5
PATIENT-FRIENDLY SUMMARY

Evaluating the impact of virtual oncology financial and legal navigation on cancer-related financial toxicity.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic