← Back to all signals
RESEARCH PAPER ANALYSIS

FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia.

AI interpretation is pending for this paper.

Open original publication →
PMID42380664
JournalLeukemia
Publication Date2026-06-30
Ingested2026-08-02 12:07 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL) remains a leading cause of cancer-related death in children and young adults. While CD19-directed chimeric antigen receptor T cell (CAR-T) therapy offers promise, high rates of long-term failure underscore the need to understand resistance mechanisms. Our studies found p53 inactivation promotes CAR-T resistance in human pre-B-ALL cell lines. Through genome-wide CRISPR/Cas9 screening of CAR-sensitive TP53-wildtype and CAR-resistant TP53-mutated CD19 + B-ALL cell lines, we found the Fatty Acid Transport Protein 2 (FATP2, encoded by SLC27A2) is a leukemia-intrinsic mechanism of CAR-T resistance in TP53-mutant B-ALL. High SLC27A2 expression in pediatric B-ALL patients correlate with worse survival outcomes following conventional chemotherapy. Using B-ALL cell lines and patient-derived xenografts, we show that FATP2-expressing TP53-mutant B-ALL resistance to CAR-T is dependent on exogenous lipid uptake to fuel fatty acid oxidation (FAO) and cell survival, which can be pharmacologically targeted through inhibition of neutral lipolysis and CPT1. These findings identify FATP2-mediated fatty acid uptake and downstream FAO as a potential target to improve existing CAR-T efficacy in human B-ALL.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Randomized controlled trial of emotion regulation therapy versus cognitive behavioral therapy to address distress in cancer caregivers. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 83.64 2 Psychosocial mediators for the impact of personal genomic risk information on melanoma prevention and early detection behaviors. Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 66.5 3 Cancer incidence and mortality in the Metropolitan Area of Bucaramanga, Colombia, 2013-2017. Colombia medica (Cali, Colombia) 39.0 4 Integrated multi-omic analysis of pediatric metastatic osteosarcoma reveals endothelial cell plasticity and lineage infidelity. bioRxiv : the preprint server for biology 46.5 5 Off-Target MAP2K7 Inhibition Drives the Antileukemic Activity of the PD-1/PD-L1 inhibitor ACS-69 in Pediatric T-ALL. Research square 61.86 6 Regional Consortia of Cancer Center Shared Resources: Models for Collaborative Infrastructure and the Emergence of a National Alliance. Journal of biomolecular techniques : JBT 54.0 7 Clinical Characteristics and Prognostic Analysis of Pediatric Acute Myeloid Leukemia With CBFB::MYH11: A 10-Year Single-Center Cohort Study. Clinical lymphoma, myeloma & leukemia 71.3 8 Distribution of molecular subtypes in a Colombian cohort of patients with acute lymphoblastic leukemia using whole-transcriptome analysis. Frontiers in oncology 56.0 9 Multimodality therapy for stage IB3 cervical cancer with a delayed diagnosis at 21 weeks of gestation: from neoadjuvant chemotherapy to adjuvant chemoradiotherapy-a case report. Frontiers in medicine 62.24 10 Association between perioperative factors and the occurrence of postoperative cerebellar mutism syndrome in children. Frontiers in neurology 60.5 11 Perceived community cervical cancer prevention support and cervical cancer screening utilization among women in Shenzhen, China: a cross-sectional study. Frontiers in public health 66.0 12 Retraction: PARC: a phase I/II study evaluating the safety and activity of pegylated recombinant human arginase BCT-100 in relapsed/refractory cancers of children and young adults. Frontiers in oncology 66.24 13 Immediate comprehensive mandibular reconstruction with fibula free flap, implant-supported dental rehabilitation, and nerve reconstruction in children: A multicenter retrospective study. Journal of plastic, reconstructive & aesthetic surgery : JPRAS 65.4 14 Fulminant Synchronous Epstein-Barr Virus-Positive MALT Lymphoma and Diffuse Large B-Cell Lymphoma Monomorphic Post-Transplant Lymphoproliferative Disorder in a Child Following Heart Transplant: A Case Report. Pediatric transplantation 55.9 15 Molecular Profiling and Clinical Characteristics of Breast Cancer in the Asir Region: a Retrospective Analysis. Clinical laboratory 64.9 16 Retrospective Analysis of HPV Infection Status and Genotyping in East China: 2023 - 2024. Clinical laboratory 57.5 17 Influence of predictors on postoperative quality of life in women with breast neoplasms. Revista brasileira de enfermagem 65.5 18 Outcomes of endoscopic sinus surgery (ESS) on sino-orbital osteomas: ophthalmic manifestations and visual outcomes from a 12-year multicenter experience and literature review. BMC ophthalmology 57.0 19 Risk of abnormal histology following vaginal hysterectomy for pelvic organ prolapse in a multi-ethnic Asian population: a two-year retrospective review. European journal of obstetrics, gynecology, and reproductive biology 61.4 20 Same-Day Radioembolization for Large Hepatocellular Carcinoma (≥ 5 cm) Using Yttrium-90 Resin Microspheres: Protocol for a Multicenter Prospective Registry Study (ISTAR-01). Cardiovascular and interventional radiology 66.0 21 Pediatric effects of forever chemicals may last for a long time. Pediatric research 60.7 22 Trajectories of pulmonary subsolid nodules in children and adolescents: a retrospective multicenter cohort study. European radiology 63.7 23 Targeting CD28 on T lineage malignancies with chimeric antigen receptor T cells. Nature communications 58.9 24 Efficacy of technology-based psychosocial interventions on quality of life and psychological outcomes in adolescent and young adult survivors of childhood cancer: a systematic review and meta-analysis of randomized controlled trials. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 77.7 25 Mental health struggles and coping strategies of individuals facing terminal illness of a loved one: A survey in a tertiary care hospital of Kolkata, West Bengal. Palliative & supportive care 61.0 26 Dual inhibition of JAK and MEK suppresses T-cell acute lymphoblastic leukemia induced by mutant IL7R and RASGRP1 overexpression. Haematologica 52.5 27 Intracranial Mesenchymal Tumor With FET::CREB Fusion Involving Lateral Ventricle: A Case Report With Review of Literature. International journal of surgical pathology 47.5 28 Community-Led Solutions to Improve Cancer Outcomes for Indigenous Children. Pediatrics 47.5 29 Supratentorial ependymoma: a comprehensive review of molecular classification, management strategies, and clinical outcomes (Part II of pediatric ependymomas across compartments). Journal of neuro-oncology 81.9 30 Sex-dependent and long-term effects of cisplatin on bone mineral density in juvenile mice. Pharmacological reports : PR 50.9 31 Insights from a Multi-Country Survey: Healthcare Providers' Perspectives on the Management of Adults with Neurofibromatosis Type 1 and Plexiform Neurofibroma. Neurology and therapy 77.6 32 Efficacy and Safety of Alectinib in Pediatric and Adult Patients with ALK-Altered Advanced Solid Tumors: a phase II TACKLE Trial (NCCH1712/MK003). Clinical cancer research : an official journal of the American Association for Cancer Research 79.0
PATIENT-FRIENDLY SUMMARY

FATP2-mediated lipid metabolism enhances chimeric antigen receptor T-cell therapy resistance in B-cell acute lymphoblastic leukemia.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic