Carfilzomib plus induction chemotherapy in children with relapsed or refractory acute lymphoblastic leukemia.
In this phase 2 study, CFZ-VXLD did not significantly improve post-induction complete remission versus a weighted external real-world control in pediatric relapsed/refractory ALL, although overall response favored CFZ-VXLD in the B-ALL subgroup.
Open original publication →What the AI sees
In this phase 2 study, CFZ-VXLD did not significantly improve post-induction complete remission versus a weighted external real-world control in pediatric relapsed/refractory ALL, although overall response favored CFZ-VXLD in the B-ALL subgroup.
Research significance
The reported B-ALL overall-response signal suggests that adding carfilzomib to VXLD may benefit a selected subset of heavily pretreated pediatric patients, but this is an inference requiring confirmation because the primary complete-remission endpoint was negative and comparisons relied on an external control.
Source abstract
We report outcomes of the phase 2 study combining carfilzomib (CFZ) plus vincristine, dexamethasone, asparaginase, and daunorubicin (CFZ-VXLD) in heavily pre-treated, pediatric patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL). We investigated whether post-induction complete remission (CR) rates after CFZ-VXLD induction are superior to an external real-world control (EC). Patients aged ≥1 month to <21 years with R/R ALL received CFZ-VXLD induction, followed by optional consolidation (experimental arm). EC arm included similar patients receiving real-world, curative-intent regimens at Therapeutic Advances in Childhood Leukemia sites between 2000-2023. Primary endpoint was CR after induction; overall response rate (ORR; CR/CR with partial/incomplete hematologic recovery/CR without platelet recovery) was a secondary endpoint. Comparative analyses used inverse probability of treatment weighting. Experimental and EC arms included 105 and 140 patients, respectively. CR rates after induction were 14.8% vs 7.8% (odds ratio [OR] 2.04; 95% CI, 0.54-7.66) in patients with B-ALL and 13.6% vs 9.1% (OR 1.58; 95% CI, 0.47-5.31) in patients with T-ALL. There was no statistically significant increase in post-induction CR for the CFZ-VXLD arm vs the EC arm and the study did not meet its primary endpoint. In patients with B-ALL, ORR was 42.6% vs 26.3% favoring the CFZ-VXLD arm vs the EC arm. Adverse event rates with CFZ were consistent with previous reports. Taken together, the CFZ-VXLD regimen may be an option for some selected pediatric patients with R/R ALL and this study highlights that novel treatments for R/R ALL remain an area of unmet medical need. NCT02303821.