← Back to all signals
RESEARCH PAPER ANALYSIS

Epidemiology and Disease Burden of Hospitalised Children With Invasive Fungal Infection in China, 2016-2022.

AI interpretation is pending for this paper.

Open original publication →
PMID42053003
JournalBritish journal of hospital medicine (London, England : 2005)
Publication Date2026-04-20
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

AIMS/BACKGROUND: Invasive fungal infection (IFI) represents a significant global health challenge, particularly in paediatric populations, due to high mortality and severe long-term sequelae. This study aimed to characterize the epidemiological patterns and quantify the disease burden of IFI among hospitalised children in China. METHODS: Data were obtained from the face sheets of discharge medical records collected between 2016 and 2022 from 30 tertiary children's hospitals, aggregated into the FUTang Updating medical REcords (FUTURE) database. Sociodemographic variables, disease spectrum, pathogen distribution, potential risk factors, length of stay (LOS), and overall disease burden among children with IFI were systematically analysed. RESULTS: A total of 1250 IFI cases were identified, revealing an upward trend in incidence since 2019. The pathogen distribution among the 485 episodes with available microbiological data included Candida (25.36%; 123/485), Aspergillus (23.71%; 115/485), Cryptococcus (22.06%; 107/485), Pneumocystis (21.44%; 104/485), Mucor (4.12%; 20/485), Talaromyces (1.24%; 6/485), Histoplasma (0.82%; 4/485), Blastomyces (0.62%; 3/485), and Sporotrichum (0.62%; 3/485). Disseminated infections accounted for 5.76% (72/1250) of all IFI. Among the 1178 non-disseminated IFI cases, pneumonia (73.34%, 864/1178), central nervous system (CNS) infections (15.53%, 183/1178), and bloodstream infections (8.66%, 102/1178) were the predominant disease types. The most prevalent risk factors were haematological malignancies and myelosuppression. Overall, 181 patients died during their hospitalisation, representing a mortality rate of 14.48%. CONCLUSION: The incidence of IFI among hospitalised children in tertiary centres in China has risen since 2019, with Candida, Aspergillus, and Cryptococcus identified as the predominant pathogens. These infections are associated with considerable mortality (14.48%). The findings highlight the urgent need for enhanced surveillance, earlier diagnosis, and targeted therapeutic strategies to reduce morbidity and mortality in this high-risk population.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Prevalence of Overweight, Obesity, and Abdominal Obesity and Their Associated Factors in Duhok City, Kurdistan Region, Iraq: A Population-Based Cross-Sectional Study. Journal of obesity 66.0 2 Childhood, adolescent, and early adult exposures and cancer risk in middle to late adulthood. Carcinogenesis 56.0 3 Exposure to per-and polyfluoroalkyl substances and early-onset cancers. Carcinogenesis 37.0 4 TPMT and NUDT15 Pharmacogenomic Profiles in Peruvian Patients With Pediatric Hematologic Malignancies. Frontiers in bioscience (Scholar edition) 66.3 5 H3F3B gene mutation in chondroblastomas: a multicenter study. Acta orthopaedica et traumatologica turcica 57.5 6 Chondroblastoma: the relationship between local invasiveness, recurrence, and histopathological features. Acta orthopaedica et traumatologica turcica 58.5 7 Neoadjuvant anti-HER2 antibody-drug conjugate SHR-A1811 in Hormone Receptor-positive, HER2-low Breast Cancer: A Phase 2 Clinical Trial (HELEN-015). Nature communications 86.12 8 Radiotherapy Reconstitutes the Collapsed miRNome of Progressive Neuroblastoma and Promotes a Favorable Tumor Evolutionary Shift. Frontiers in bioscience (Landmark edition) 65.64 9 [Surgical highlights of 2026 Rhinology Annual Conference: endoscopic resection of a juvenile nasopharyngeal angiofibroma with subdural intracranial extension]. Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 28.5 10 A multicenter international case series highlighting the management of pediatric nephrogenic adenoma. Journal of pediatric urology 58.9 11 The BCG Vaccine: Pharmacological Biotechnology and Expanding Immunological Horizons. Frontiers in bioscience (Elite edition) 70.5 12 Synergistic antitumor effect of HMGB2 targeting combined with MDM2 inhibitor in diffuse intrinsic pontine glioma therapy. Frontiers in oncology 59.9 13 Pediatric ectodermal dysplasia with immunodeficiency caused by a hemizygous IKBKG frameshift variant: a case report and literature review. Frontiers in immunology 73.1 14 Allogeneic hematopoietic stem cell transplantation is associated with improved survival compared with chemotherapy in patients with acute myeloid leukemia harboring favorable-risk genetic features at initial diagnosis: a single-center retrospective study. Frontiers in immunology 79.76 15 Haematological toxicity associated with antineoplastic drugs: a pharmacovigilance analysis based on the FDA adverse event reporting system database. Frontiers in immunology 63.8 16 Development of a multidimensional disease burden assessment system for childhood neuroblastoma based on the social determinants of health theory. Frontiers in oncology 57.2 17 Case Report: Reconciling genomic ambiguity with clinical certainty in refractory panniculitis. Frontiers in immunology 50.72 18 Vitamin D signaling in thymic development and longevity. Frontiers in nutrition 42.1 19 Endobronchial fibroepithelial polyp presenting as persistent wheezing in a 9-year-old girl: a case report. Frontiers in pediatrics 50.3 20 Treatment patterns, intensive treatment, and hospitalization-related burden of juvenile generalized myasthenia gravis in Japan: a retrospective cohort study using a hospital-based claims database. Frontiers in neurology 77.64 21 Two-decade clinicopathological spectrum of gliomas at a tertiary center in LMIC: histological profile and the molecular diagnostic gap. Frontiers in oncology 64.9 22 Giant Mesenteric Cyst: A Case Series. International medical case reports journal 56.9 23 Application of Dual-Energy X-Ray Absorptiometry for Bone Mineral Density Screening in Pediatric, Adolescent, and Young Adult Cancer Survivors: A Multi-Institutional Study of 6 California Children's Hospitals. Journal of pediatric hematology/oncology 61.5 24 Childhood cancer and future cardiometabolic health. npj metabolic health and disease 56.9 25 Baseline Environmental Contamination Data and Model-based Screening of Children's Exposure-Risk Estimates from Metal(loid)-laden Vegetables and Soils. Toxicological sciences : an official journal of the Society of Toxicology 61.5 26 Beyond standard care: Fathers' perspectives on healthcare and related support services when caring for a child with a progressive life-limiting condition-A qualitative study. Palliative medicine 56.0 27 Bortezomib-based chemotherapy in Chinese pediatric patients with relapsed/refractory acute lymphoblastic leukemia: A single-center retrospective study. Pediatric investigation 79.78 28 Succinate dehydrogenase (SDHB, SDHC, SDHD) gene variants significantly modify clinical outcomes in paraganglioma-pheochromocytoma but have a limited impact on head and neck paraganglioma. Genetics in medicine : official journal of the American College of Medical Genetics 63.0 29 Cervicothoracic dumbbell ganglioneuroblastoma with spinal canal involvement and bone marrow metastasis: a case report and systematic review. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 76.3 30 Pediatric osteoporosis: a comprehensive imaging-based review of diagnosis, differential diagnosis, and etiology. Skeletal radiology 58.4 31 Frameless VarioGuide biopsy for pediatric brainstem lesions in the molecular era: diagnostic performance and workflow characteristics in a comparative single-center series. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 59.9 32 Isolated clival Langerhans cell histiocytosis in a pediatric patient: systematic review and illustrative case report. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 75.8
PATIENT-FRIENDLY SUMMARY

Epidemiology and Disease Burden of Hospitalised Children With Invasive Fungal Infection in China, 2016-2022.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic