← Back to all signals
RESEARCH PAPER ANALYSIS

Predictors of complete molecular response and impact of allogeneic hematopoietic stem cell transplantation on outcome in patients with Philadelphia chromosome positive acute lymphoblastic leukemia (ALL): results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND).

AI interpretation is pending for this paper.

Open original publication →
PMID41954351
JournalLeukemia & lymphoma
Publication Date2026-04-09
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

With the advent of tyrosine kinase inhibitors (TKIs), the outcomes of patients with Philadelphia positive acute lymphoblastic leukemia (Ph + ALL) improved. We conducted a retrospective multicenter study of 467 adult patients with Ph + ALL (2003-2023) evaluating predictors of complete molecular response (CMR) at 3 months and its impact on outcomes. CMR was achieved in 297(63.7%) patients. In the multivariate analysis, WBC > 70,000/L at diagnosis (p = 0.01), p210 BCR::ABL1 fusion (p < 0.001) and monosomy 7 (p = 0.007) were independently associated with failure to achieve CMR, while use of ponatinib or dasatinib (p = 0.008) and intensive chemotherapy (IC) (p = 0.009) predicted higher CMR. Among patients who achieved CMR, the median relapse-free survival (RFS) was significantly better (123.1 vs. 30.3 months, p < 0.0001), however, overall survival (OS) was not significantly different (129.2. vs. 149.3 months, p = 0.07) with or without allogeneic hematopoietic cell transplantation (allo-HCT). These findings suggest that allo-HCT may be deferred in selected patients achieving early CMR, although prospective validation is needed.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Retinoblastoma Metastatic to Bone: Case Series and Literature Review. Journal of radiology case reports 53.4 2 Pediatric Plantar Malignant Melanoma, Subungual Melanoma, and Spitzoid Melanoma: A Case Series of Rare Pediatric Melanomas. The Journal of clinical and aesthetic dermatology 48.5 3 Inborn errors of immunity and mortality: 10 years of single-center experience. Allergologia et immunopathologia 60.5 4 Regional Diversity of Human Papillomavirus Genotypes in Southeastern Brazil: Implications for Cervical Cancer Screening. Journal of medical virology 61.0 5 Epidemiology and Survival Determinants of Monomorphic Epitheliotropic T-Cell Lymphoma: A Pooled Patient-Level Dataset Analysis. Hematological oncology 74.52 6 Knowledge, attitudes, and practices regarding Helicobacter pylori-induced gastric ulcers and cancers among Saudi residents: a nationwide web-based survey. Frontiers in public health 70.4 7 Adult psychological outcomes among women with different adolescent PCOS presentations. Frontiers in endocrinology 59.5 8 Computational insights into synergistic mechanisms of PD-901 and 5-azacitidine targeting PTPN11 (SHP2) E76K mutation in juvenile myelomonocytic leukemia. Frontiers in bioinformatics 62.85 9 Clinical evidence and biological mechanisms linking obesity to adverse outcomes in pediatric and adolescent acute lymphoblastic leukemia. Frontiers in oncology 68.95 10 [Comparison of inpatient disease statistics based on two coding rules]. Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 61.9 11 Serum HMGB3 and PCSK9 Levels as Predictors of Early Treatment Response in Pediatric Mycoplasma pneumoniae Pneumonia: A Single-Center Prospective Cohort Study. International journal of general medicine 79.26 12 Prevalence and penetrance of heritable retinoblastoma in two adult population cohorts: implications for genomic newborn screening. European journal of human genetics : EJHG 65.5 13 A mixed methods study of adolescent and young adult cancer survivors and their utilization of a survivorship clinic: Barriers and facilitators. Journal of cancer survivorship : research and practice 65.9 14 Perinatal Characteristics of Japanese Children With Infantile Hemangioma: A Questionnaire-Based Case-Control Study. The Journal of dermatology 67.0 15 Efficacy of celecoxib and methotrexate-vinblastine regimen in desmoid-type fibromatosis: A retrospective cohort study. Medicine 76.0 16 The safety and efficacy of different anti-tuberculosis regimens containing Lzd for RR/MDR/Pre-XDR-TB patients in China. Medicine 68.2 17 Nursing care of a pediatric patient with anti-NMDAR encephalitis complicated by secondary epilepsy: A case report. Medicine 61.1 18 Cardiac involvement in neurofibromatosis type 1: real-world baseline and follow-up findings from a tertiary single-center cohort. European journal of pediatrics 62.9 19 Multimodal clinical-radiomic-deep learning model for preoperative classification of pediatric pineal region tumors. Neuroradiology 70.4 20 Precision medicine for pediatric gliomas. Current opinion in oncology 80.34 21 Parental distress - a predictor of treatment adherence in pediatric neuroblastoma: a cross-sectional study of chinese families. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 62.24 22 Integrating optimal patient-centered care: patient- and family-reported experiences after complex treatment for rare diseases. World journal of pediatrics : WJP 63.94 23 [Guidelines for the diagnosis and treatment of hemophagocytic lymphohistiocytosis (2026 edition)]. Zhonghua yi xue za zhi 73.84 24 Cranial MRI in Girls With Central Precocious Puberty: Clinical Characteristics and Predictors of Abnormal Findings. Saudi medical journal 69.8 25 Diffuse midline glioma, H3 K27-altered, forming a suprasellar mass: A case report. Radiology case reports 51.9 26 Integrating immunophenotyping and morphology in the diagnosis of acute leukemia at the National Oncology Center, Sana'a, Yemen. The Libyan journal of medicine 61.0 27 Not Just a Pediatric Condition: Down Syndrome Across the Lifespan. Missouri medicine 54.0 28 The incidence of thyroid cancer in Danish children, adolescents and young adults. Danish medical journal 56.0 29 Cancer in Young Women: Late-Stage Breast Cancer Registry Analysis of a 24-Year Nationwide Retrospective Cohort of 52,734 Patients in Brazil (CLARA Study). Clinical breast cancer 71.0 30 Pediatric Familial Cerebral Cavernous Malformation Associated With a Novel KRIT1 Initiation-Region Frameshift Variant. Molecular genetics & genomic medicine 56.0 31 Social Inequalities, Geographical Accessibility to Care, and Excess Mortality for Patients With Hematological Malignancies in France: Results From French Cancer Registries. Hematological oncology 65.2 32 Bibliometric and clinical trial landscape of hepatoblastoma (2000-2024): a multi-database analysis of global research. Frontiers in oncology 77.1
PATIENT-FRIENDLY SUMMARY

Predictors of complete molecular response and impact of allogeneic hematopoietic stem cell transplantation on outcome in patients with Philadelphia chromosome positive acute lymphoblastic leukemia (ALL): results from the Consortium on Myeloid Malignancies and Neoplastic Diseases (COMMAND).

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic