← Back to all signals
RESEARCH PAPER ANALYSIS

Graft survival and prognostic factors of recycled autografts after limb salvage surgery in patients with sarcoma of the long bone: a systematic review and meta-analysis of individual participant data.

AI interpretation is pending for this paper.

Open original publication →
PMID41796355
JournalJournal of orthopaedic surgery and research
Publication Date2026-03-08
Ingested2026-08-02 12:06 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND: Recycled autografts are widely used in limb salvage surgery for patients with long-bone defects due to bone sarcoma resection. Currently, there are limited number of studies to sufficiently estimate graft survival and its modes of failure. PURPOSE: We aim to assess the survival probability of recycled autografts and its associated prognostic factors in limb salvage surgery of long-bone sarcoma. METHODS: We performed a systematic search from PubMed, Embase and Scopus. Observational studies and case series reporting graft survival outcomes with follow-up data were included. Graft survival probabilities at 1, 2, 5, and 10 years were pooled. Using data of individual participant data (IPD), prognostic factors associated with poor graft survival and mean survival time for the recycled autograft were identified using multivariable flexible parametric regression. RESULTS: A total of 2388 articles were identified. Twenty-eight studies with 395 patients were eligible. The median age of the patients was 20 years (interquartile range, 15-34) and approximately half of them were male. From study-level meta-analysis, the pooled graft 5-year survival probability of the recycled autograft was 91.0% (95%CI 85.4-95.6; I2 49.6%; very low certainty of evidence). From IPD analysis, male gender, femur and tibia osteoarticular resections were significantly associated with poor graft survival rates comparing to intercalary resection. Furthermore, infection ranked the most observed cause among all failures. CONCLUSION: The recycled autograft may offer a feasible limb-salvage option for long-bone sarcomas. With individual participant data, our results suggest factors that associated with poor graft survival. However, further prospective studies with large sample size focusing on graft survival would be needed.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Hypothalamic obesity following craniopharyngioma surgery: What is the role of hypothalamic T2 signal changes in brain MRI? Neuro-oncology advances 61.9 2 Personalized Perioperative Music Listening: A Human-Centered Approach to Precision Anesthesia. Cureus 74.2 3 Adult Congenital Pulmonary Airway Malformation Presenting With a Large Cystic Lung Lesion: A Case Report. Cureus 47.5 4 Spinal Myeloid Sarcoma Revealing Acute Myeloid Leukemia in a Child: A Case Report. Cureus 54.3 5 A Non-enhanced CT Dataset for Differential Diagnosis of Pediatric Extracranial Germ Cell Tumors. Scientific data 57.0 6 Female cancers in adolescent and young adult women: global inequities and 2050 burden estimates from GLOBOCAN 2022. Frontiers in oncology 61.1 7 Knowledge of cervical cancer screening, barriers to awareness, and the role of technological interventions in improving screening uptake: a scoping review protocol. Frontiers in health services 78.8 8 Resources are associated with functional outcome and brain morphometry in childhood cancer survivors. Frontiers in oncology 63.9 9 Immunogenicity, efficacy, and safety of different dose schedules of human papillomavirus vaccines: a Bayesian network meta-analysis of randomized controlled trials. Frontiers in immunology 81.32 10 Case Report: Synchronous ALK-positive laryngeal inflammatory myofibroblastic tumor and EGFR-mutant lung adenocarcinoma in a child. Frontiers in pediatrics 48.5 11 Case Report: Anti-GQ1b antibody-positive overlap syndrome: a pediatric case involving the brainstem, spinal cord, and peripheral nerves. Frontiers in immunology 59.66 12 Hunger, satiety, and eating behavior after craniopharyngioma - narrative review on current management and future therapeutic perspectives. Frontiers in endocrinology 82.34 13 Awareness and Acceptance of the Human Papillomavirus (HPV) Vaccine and Associated Factors Among Parents of Adolescents (9-18 Years) at a Children's Hospital in Babol, Iran: A Cross-Sectional Study. Health science reports 63.7 14 Long-term complications after total body irradiation in children younger than 4 years transplanted for acute lymphoblastic leukemia. Bone marrow transplantation 62.4 15 Fertility and Birth Outcomes in Rheumatoid Arthritis: A Narrative Review. Rheumatology and therapy 63.6 16 Characteristics and outcome of T-cell/histiocyte-rich large B-cell lymphoma in childhood and adolescence: An international retrospective analysis. British journal of haematology 28.5 17 Benign and Malignant Conjunctival Lesions in Children. Seminars in ophthalmology 51.5 18 Clinical characteristics, management and outcomes in immune checkpoint inhibitor-induced central nervous system demyelinating disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 85.76 19 Preoperative Speech Impairments as Precursors of Posterior Fossa Syndrome in Children with Brain Tumours. Cerebellum (London, England) 65.9 20 Invasive Fusarium Infections in Immunocompromised Children: A 10-year Multicenter Retrospective Study and Literature Review. The Pediatric infectious disease journal 76.5 21 Rhabdomyosarcoma Mimicking Otomastoiditis in a Preschool Child with Facial Paralysis. Ear, nose, & throat journal 56.0 22 Cyst wall enhancement is associated with local recurrence after resection of intracranial hemangioblastoma: an exploratory retrospective cohort study. Journal of neuro-oncology 64.7 23 Correction to "Single-Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients". Advanced science (Weinheim, Baden-Wurttemberg, Germany) 47.5 24 Erratum. International archives of allergy and immunology 89.0 25 The Childhood Cancer and Leukemia International Consortium (CLIC): Expanding global collaboration in pediatric cancer etiology research. Cancer epidemiology 64.2 26 Aminosalicylate use Increases Corticosteroid Exposure and Decreases Biologic Durability in Pediatric Crohn's Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 68.3 27 Inadequate Energy and Micronutrient Intakes Across Filipino Population Groups: Findings from the 2021 Expanded National Nutrition Survey (ENNS). The Journal of nutrition 67.5 28 Paediatric tracheal carcinoid with carinal involvement and nodal metastasis: challenging airway reconstruction with oncological clearance. BMJ case reports 56.0 29 Acute abdomen in pregnancy revealing sigmoid colon carcinoma at caesarean section. BMJ case reports 58.4 30 Archegonous cystic odontoma: expanding the spectrum of hybrid odontogenic lesions. BMJ case reports 56.0 31 Selective retinal arterial whitening in retinal astrocytic hamartoma in tuberous sclerosis. BMJ case reports 48.5 32 Appendicovesical fistula in a child with acute myeloid leukaemia. BMJ case reports 47.9
PATIENT-FRIENDLY SUMMARY

Graft survival and prognostic factors of recycled autografts after limb salvage surgery in patients with sarcoma of the long bone: a systematic review and meta-analysis of individual participant data.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic