Temporal trends of early-onset cancers among Canadian jurisdictions covered in the CiNA dataset.
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OBJECTIVE: To assess temporal trends in early-onset cancers across Canadian jurisdictions covered in the CiNA dataset (2010-2022). METHODS: The Cancer in North America (CiNA) dataset (2010-2022) was accessed, and data from nine Canadian cancer registries (representing approximately 38.5% of the Canadian population) were reviewed. Among individuals with early-onset cancers (15-39 years old), age-adjusted Annual Percent Change (APC) was assessed for all cancers, and for individual cancers, for different Canadian jurisdictions included in the dataset. RESULTS: Within the age group of 15-39 years old, incidence significantly increased during the study period (age-adjusted rate was 60 per 100,000 in 2010 vs 63.9 per 100,000 in 2022; age-adjusted APC=0.5 (95% CI: 0.1-0.9)). On further stratification, the trend has significantly increased for those aged 30-39 years old (age-adjusted APC=1 (95% CI: 0.6-1.5)), while it was significantly decreased for those aged 20-29 years old (age-adjusted APC=-0.7 (95% CI: -1.2 to -0.3)). When stratified by sex, age-adjusted APC for early-onset cancer diagnosis was significant for women (APC=0.9; 95% CI: 0.5-1.2), but not for men (APC=-0.1; 95% CI: -0.8-0.6). CONCLUSIONS: Early-onset cancers have increased in Canadian jurisdictions covered in the CiNA dataset 2010-2022, particularly among the age group of 30-39 years old. More work is needed to improve prevention, early detection, and develop a dedicated management approach to this group of patients with special needs.