[Analysis of dermoscopic and histopathological features in misdiagnosed cases of early mycosis fungoides].
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Retrospectively, patients who were pathologically diagnosed with early-stage mycosis fungoides (MF) in the Department of Dermatology, Zhongshan Hospital Affiliated to Xiamen University, from October 1, 2023 to April 1, 2024 and had a history of misdiagnosis were enrolled in this study. Their clinical characteristics, dermoscopic manifestations of skin lesions as well as cutaneous histopathological features were analyzed. A total of 10 patients with early-stage MF were included, among whom 8 were males and 2 were females, with a mean age of (30.1±14.3) years. Dermoscopic examination revealed that all patients presented with a dark yellowish-red background accompanied by patchy orange-yellow areas. The main vascular pattern in most cases (9/10) was "spermatozoa-like vessels", and dotted vessels as well as short linear vessels were observed in all 10 cases. Histopathological examination showed vacuolar interface change accompanied by superficial perivascular inflammation pattern in all cases, together with lymphocytic epidermotropism, intraepidermal atypical lymphocytes and Pautrier microabscesses. After standardized treatment, follow-up dermoscopic examinations were performed one year later, and the aforementioned dermoscopic manifestations disappeared in 9 patients. This study suggests that early-stage MF with different clinical phenotypes has relatively consistent dermoscopic and cutaneous histopathological features.