Sebaceous adenocarcinoma of the parotid gland: review and analysis of the literature.
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Primary sebaceous adenocarcinoma (SAC) of the parotid gland is extremely rare, and because of its rarity, its behaviour is not fully understood. The aim of this study was to clarify the behaviour of SAC of the parotid gland, including the main features and their relationships to the prognosis. Sixty-six reported cases of the disease were identified and included in the study, and these were reviewed and analysed. SAC of the parotid gland occurred in patients aged 6-92 years, with a bimodal age distribution (20 s and 50-70 s). Of the 66 patients, 59% were female and 41% were male, giving a male to female ratio of 1:1.4. The prognosis was statistically superior for cases without perineural invasion (P = 0.030), those in age group <70 years when compared ≥70 years (P = 0.008), primary cases when compared to secondary cases (P = 0.009), and cases in which the primary treatment was surgery only (P = 0.007). The results showed that in SAC of the parotid gland, the death rate from cancer (66.7%) was higher than that for skin SAC, while the 5-year survival rate (71.4%) was lower than that in skin SAC.