PET/Computed Tomography and PET/MR Imaging in Pediatric Osteosarcoma and Ewing Sarcoma: A Comprehensive Review.
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Pediatric osteosarcoma and Ewing sarcoma are aggressive primary bone tumors requiring precise diagnosis and staging. 18F-FDG PET/computed tomography and PET/MRI are essential for staging, treatment monitoring, and clinical decision-making. PET/MRI provides enhanced soft-tissue contrast and reduced radiation exposure, making it well-suited for long-term surveillance in pediatric patients. Emerging molecular probes demonstrate potential for tumor-specific imaging, although their clinical utility has yet to be explored. This review aims to summarize the applications, limitations, and future directions of PET imaging in the precision diagnosis and management of pediatric osteosarcoma and Ewing sarcoma.