[Clinical Characteristics and Prognosis of Children with Hematological Malignancies Complicated by Secondary Hemophagocytic Lymphohistiocytosis].
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OBJECTIVE: To analyze the clinical characteristics and prognosis of children with hematological malignancies complicated by secondary hemophagocytic lymphohistiocytosis (HLH). METHODS: A total of 67 children with HLH admitted to Jinan Second Maternal and Child Health Hospital between June 2020 and June 2024 were selected. Children without hematological malignancies were divided into the non-combined group, and those with hematological malignancies were divided into the combined group. The clinical characteristics and prognosis of the two groups were analyzed. RESULTS: There were no significant differences in clinical characteristics such as WBC, Hb, PLT between the two groups (P ＞0.05). During the follow-up, the 1- and 2-year overall survival (OS) rates for all children were (88.6±4.1)% and (73.1±7.7)%, respectively. In the non-combined group, 43 children survived and 6 died, with 1- and 2-year OS rates of (95.2±3.3)% and (77.4±9.3)%, respectively. In the combined group, 12 children survived and 6 died, with 1- and 2-year OS rates of (71.8±10.7)% and (62.8±12.6)%, respectively. The OS rate of the combined group was significantly lower than that of the non-combined group (χ2=4.787, P =0.029). The 1- and 2-year event free survival (EFS) rates of the combined group were (61.1±11.5)% and (50.9±13.3)%, respectively. CONCLUSION: Children with hematological malignancies complicated by secondary HLH exhibit complex and diverse clinical characteristics. Although favorable short-term therapeutic effects can be achieved, their long-term prognosis tends to be less optimistic.