Sclerotic Head and Neck Paragangliomas: An Unfavorable Indicator Associated With Surgical Outcomes.
AI interpretation is pending for this paper.
Open original publication →What the AI sees
Not AI summarized yet.
Research significance
Pending deeper interpretation.
Source abstract
BACKGROUND: This retrospective case-control study investigated surgical outcomes of head and neck paragangliomas (HNPGLs) with varying degrees of sclerosis. METHODS: Data from 95 patients who underwent HNPGL surgery over 20 years were analyzed. Based on histology, tumors were classified as having non-significant (< 30%) or significant (≥ 30%) sclerosis. RESULTS: Seventy patients had non-significant sclerosis and 25 had significant sclerosis. The significant sclerosis group was younger (39 vs. 44 years, p = 0.026), had more multiple tumors (48% vs. 12.9%, p = 0.001), higher nerve injury rates (p = 0.021), and more vascular injuries (20.8% vs. 4.17%, p = 0.022). Multivariate analysis identified tumor volume (OR = 1.014, p = 0.005) and sclerosis degree (OR = 0.276, p = 0.013) as independent risk factors for severe complications involving both nerve and vascular injury. CONCLUSION: Sclerotic HNPGLs are associated with earlier onset, multiple tumors, and increased risk of intraoperative complications, suggesting unfavorable surgical outcomes.