← Back to all signals
RESEARCH PAPER ANALYSIS

Individualized Dosimetry to Guide LuTATE Therapy in Pediatric Neuroblastoma.

AI interpretation is pending for this paper.

Open original publication →
PMID41221389
JournalWorld journal of nuclear medicine
Publication Date2025-10-09
Ingested2026-08-02 12:05 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Neuroblastoma is the most common extracranial solid tumor in children. Tumor heterogeneity is a hallmark of neuroblastoma and prognosis can be dismal in the presence of high-risk factors such as N-myc gene amplification, aneuploidy, genetic rearrangement, and age at presentation. I-131 MIBG therapy has traditionally been the radionuclide therapy agent used in pediatric neuroblastoma and is incorporated in many treatment protocols. The high cost and limited availability of I-131 MIBG and the required radiation safety measures are barriers to its widespread use. LuTATE has emerged as a more practical radionuclide therapy agent requiring less stringent radiation safety measures and coupled with GaTATE PET/CT forms a potentially useful theranostic pairing for children with neuroblastoma. LuTATE therapy in adults with neuroendocrine tumors uses an empiric dosing schedule with good results. However, a previous study using empiric dosing of LuTATE in pediatric neuroblastoma was not shown to be effective. We present our use of individualized patient dosimetry to optimize the dose of LuTATE in three children with relapsed/resistant neuroblastoma.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Awareness, Accessibility, Authenticity, and Appropriateness: Multilevel Determinants of Research Engagement Among Underrepresented AYA Cancer Survivors. Cancer control : journal of the Moffitt Cancer Center 58.0 2 The Clinical Impact of End-of-Consolidation Measurable Residual Disease in High-Risk Pediatric B-Cell Acute Lymphoblastic Leukemia. Cancer control : journal of the Moffitt Cancer Center 72.4 3 Ischemic stroke as the first manifestation of acute promyelocytic. Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) 60.8 4 CAR-T Versus Non-CAR-T Bridging Strategies Before Allogeneic Hematopoietic Stem Cell Transplantation in Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia: A Systematic Review. Cureus 87.84 5 p53 and β-Catenin Expression in Gallbladder Carcinoma: Translational Insights for Pediatric Cancer Biology. Asian Pacific journal of cancer prevention : APJCP 64.4 6 Expression of miR-214 in Pediatric Acute Leukemia: Correlations with Leukemia Subtypes, Familial Predisposition, and Hepatitis B Virus Infection. Asian Pacific journal of cancer prevention : APJCP 57.5 7 Relative Survival Rates of Pediatric Patients with Solid Tumours in Khon Kaen, Thailand. Asian Pacific journal of cancer prevention : APJCP 60.02 8 A Cross-Sectional Study of Knowledge, Attitudes, and Perceptions toward HPV Vaccination Among Undergraduate Students Studying in Sarawak, Malaysia. Asian Pacific journal of cancer prevention : APJCP 59.5 9 Breast Cancer-Related Quality of Life among Women Undergoing Treatment: A Hospital-Based Study in Vietnam. Asian Pacific journal of cancer prevention : APJCP 74.84 10 Tobacco Consumption, Early Initiation, and Determinants Among School-Going Adolescents in Ranchi, Jharkhand: A Cross-Sectional Study. Asian Pacific journal of cancer prevention : APJCP 59.0 11 Case 354. Radiology 58.4 12 CAF-derived BHB modulates FXR1-Kbhb and NK-cell lipid metabolism in osteosarcoma. International journal of biological sciences 70.3 13 Consensus recommendations for the diagnosis and management of hemophagocytic lymphohistiocytosis in the Gulf Cooperation Council: a modified Delphi approach. Frontiers in immunology 63.5 14 Meridian-based traditional Chinese medicine interventions for supportive care in children, adolescents, and young adults with cancer: a systematic review and meta-analysis. Frontiers in pediatrics 85.7 15 Adipose tissue: an overlooked target of medical ionizing radiation and its metabolic consequences. Frontiers in public health 60.6 16 Navigating the immunosuppressive abyss: current hurdles and innovative breakthroughs in neoadjuvant immunotherapy for osteosarcoma. Frontiers in immunology 72.82 17 Subperiosteal lesions: a radiologic spectrum of pathologies and diagnostic considerations. Clinical imaging 55.2 18 Primary Hyperparathyroidism Presenting as a Distal Femur Pathologic Fracture in an Adolescent: A Case Report. JBJS case connector 47.9 19 Femoral Neck System and Cement Augmentation for Temporizing a Pathologic Hip Fracture in Osteosarcoma: A Case Report. JBJS case connector 49.9 20 Sexual dysfunction in women with gestational trophoblastic disease: a cross-sectional study in Recife, Pernambuco, Brazil. PeerJ 59.5 21 Prophylactic thyroidectomy in pediatric multiple endocrine neoplasia type 2: A single-institution case series. International journal of pediatric otorhinolaryngology 56.5 22 Hereditary Predisposition to Acute Myeloid Leukemia: A Novel Germline CEBPA Mutation in a Multigenerational Family. Case reports in hematology 63.5 23 Diagnostic yield of cancer predisposition in a nationwide prospective childhood acute leukemia cohort. Nature communications 62.4 24 Semaglutide for Treating Paediatric Craniopharyngioma-Related Obesity: A Multicentre Case Series. Diabetes, obesity & metabolism 74.2 25 Individualized Patient Education Using Virtual Reality to Prepare Families for Solid Tumor Surgery in Pediatric Oncology. Pediatric blood & cancer 59.9 26 Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish-Speaking Caregivers of Children With Cancer. Pediatric blood & cancer 57.2 27 Analysis of Epstein-Barr Virus and Tumor-Derived Circulating Plasma DNA in Children and Young Adults With Classical Hodgkin Lymphoma in East Africa. Pediatric blood & cancer 61.2 28 Use of dietary supplements and over-the-counter products among adults with a self-reported history of cancer in Poland. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 59.9 29 Machine learning and computational approaches to model therapeutic response and resistance in diffuse midline glioma. Journal of neuro-oncology 66.76 30 Predicting early recurrence of craniopharyngioma using multi-omics radiomic modeling: a retrospective cohort study. Neurosurgical review 67.0 31 Beyond Nerve Hyperexcitability: Potential Implications of Cerebrospinal Fluid CASPR2 Antibodies for Central Pain Processing in Isaacs Syndrome: A Case-Based Systematic Review. Pain and therapy 78.5 32 Definitive surgical outcomes in children with advanced hepatoblastoma (PRETEXT III-IV): A retrospective single-center canadian experience. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 68.5
PATIENT-FRIENDLY SUMMARY

Individualized Dosimetry to Guide LuTATE Therapy in Pediatric Neuroblastoma.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic