← Back to all signals
RESEARCH PAPER ANALYSIS

Clinical, Radiographic and Histopathological Analysis of Cemento-Ossifying Fibromas and Fibro-Osseous Lesions of the Oral and Maxillofacial Region: A 53-Year Retrospective Study and Update of Current Concepts.

AI interpretation is pending for this paper.

Open original publication →
PMID40928053
JournalJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Publication Date2025-09-10
Ingested2026-08-02 12:05 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND: Fibro-osseous lesions (FOL) of the jawbones and cemento-ossifying fibroma (COF) represent a heterogeneous group of lesions with overlapping histopathological features and variability in biological behavior. Thus, this study aimed to evaluate the clinical, radiographic, and histopathological characteristics of FOLs (cemento-osseous dysplasia-COD, fibrous dysplasia-FD, ossifying fibroma-OF) as well as COF, diagnosed at a reference center in oral pathology over 53 years. METHODS: Sex, age, symptoms, clinical diagnosis, time of evolution, anatomical site, size of the lesion, and radiographic characteristics were collected from all cases of lesions previously diagnosed as FOLs. RESULTS: Among 19 600 cases of oral and maxillofacial lesions diagnosed at our center, 156 (0.8%) had a histological diagnosis of FOL, with COD being the most common (37.2%). Radiographically, most cases presented as unilocular lesions (64.3%) (p = 0.034) with mixed radiolucency (53.8%). COD and COF frequently exhibited well-defined borders. Additionally, 50% of COD cases displayed a cotton-wool appearance, while half of FDs appeared as ground-glass opacifications. Histopathologically, a significantly high frequency of lamellar bone was observed in all types of FOL (p = 0.0001). In contrast, peritrabecular clefting was significantly found in FDs, and cementum-like tissue in CODs and COFs (p < 0.05). Lesional bone fusing with the normal adjacent bone was more significantly observed in COD and FD (p = 0.001). CONCLUSION: A definitive and accurate diagnosis of FOL is achievable when cases are individually investigated, and all clinical, radiographic, and histopathologic features are analyzed.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Pediatric Brain Tumors: A Clinicopathological Study and Assessment of Caregiver Quality of Life at a Tertiary Neurosurgical Referral Center in Northern India. Cureus 68.7 2 PLPP1 inhibits Wnt/β-catenin signaling via enhancing Caveolin-1/β-catenin interaction and is negatively regulated by c-Myc in osteosarcoma. Journal of orthopaedic translation 58.8 3 Manifestations of Body Image Distress in AYA Cancer Survivors: A Qualitative Analysis of Participants in an Expressive Writing Intervention. Psycho-oncology 58.7 4 Development and Evaluation of a Population Pharmacokinetic Model for High-Dose Methotrexate in Japanese Pediatric Patients with Acute Lymphoblastic Leukemia. Journal of clinical pharmacology 65.92 5 Ventilation Strategies in a Pediatric Patient Undergoing Resection and Anastomosis for a Juxta Carinal Tumor. Annals of cardiac anaesthesia 54.0 6 Effect of a Single Subanesthetic Dose of Esketamine on Gastrointestinal Recovery After Laparoscopic Colorectal Cancer Surgery: A Randomized, Outcome-Assessor-Blinded, Placebo-Controlled Trial. Drug design, development and therapy 78.12 7 Effectiveness of psychosocial interventions addressing informal caregivers' mental health: an umbrella systematic review with 26,481 participants. Clinical psychology review 78.2 8 Diagnostic Variability in the Modified Kocher Criteria for Septic Arthritis of the Hip: Implications for Aspiration Decision-Making. Pediatric emergency care 74.8 9 Spirituality in Multicultural Pediatric Oncology End-of-Life Care: Four Cases. Clinical pediatrics 56.0 10 Proton Radiotherapy Decreases Incidence of Radiation-Induced Second Malignant Neoplasms Compared to Photon Radiotherapy in Patients With Retinoblastoma. Pediatric blood & cancer 62.94 11 Globalising the access to advanced molecular diagnostics of CNS tumors: Experience of the Molecular Neuro-Pathology (MNP) Outreach Consortium. Neuro-oncology 59.6 12 Vaccination for girls and women across the life course: Evidence-based recommendations for clinical practice and policy. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 58.0 13 Impact of Initial Treatment Setting on Survival in Relapsed Pediatric and AYA Bone Sarcomas: A Secondary Analysis of a Prospective Clinical Trial. Pediatric blood & cancer 81.08 14 Bone and Soft Tissue Neoplasms in Infants Versus Older Children: A Report From the Cancer in Young People in Canada Program. Pediatric blood & cancer 69.3 15 CT-guided methylene blue staining to facilitate thoracoscopic resection of intermediate-to-deep pulmonary metastases in pediatric patients. Pediatric surgery international 63.6 16 Neighborhood socioeconomic opportunity and clinical presentation, recurrence, and longitudinal treatment intensity in adolescent pilonidal disease. Pediatric surgery international 72.14 17 Cancer history, rural residence, and genetic cancer risk testing engagement among U.S. adults. Cancer causes & control : CCC 59.0 18 Understanding and clinical approach to early T-cell precursor acute lymphoblastic leukemia. Blood research 81.5 19 Plasma proteomic signatures in bipolar disorder and their implications for data-driven patient stratification. Brain, behavior, and immunity 67.5 20 Mothers' emotional and caregiving experiences during the first month after a child's acute lymphoblastic leukemia diagnosis: A qualitative study. Asia-Pacific journal of oncology nursing 57.2 21 MRI-guided cryoablation for recurrent pediatric hand desmoid tumor: A longitudinal case report. Radiology case reports 49.9 22 Maternal smoking and risk of childhood cancer: a report from the Childhood Cancer and Leukemia International Consortium. International journal of epidemiology 64.0 23 Profile of Invasive Fungal Infections in a Paediatric Haemato-Oncology Unit: A Five-Year Retrospective Cohort Study From a Tertiary Care Centre in South India. Cureus 70.8 24 Prevalence and risk factors of persistent and neuropathic pain following resection of pediatric extremity soft tissue sarcomas: A nationwide cohort study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 69.4 25 Neonatal airway emergency: congenital laryngeal myxoma. Journal of surgical case reports 47.9 26 Burkitt Lymphoma Presenting as Renal Failure: Learning From Diagnostic Pitfalls in Pediatrics. Clinical case reports 51.5 27 Reference frame for Adult Brainstem gliomas. The oncologist 68.2 28 Pharmacogenomics of cancer therapy-related cardiomyopathy in childhood cancer survivors. Pharmacogenomics 68.44 29 HPV Vaccination Uptake Among Children Attending Polish Primary Schools and Parental Factors Influencing Vaccination: A Cross-sectional Study. Journal of community health 59.0 30 Social Media and HPV Vaccine Hesitancy: How Misinformation Affects Latino Parents. Journal of community health 63.2 31 Overcoming Primary Graft Failure in Pediatric Allogeneic HSCT: Insights from Ten Centers of the Spanish Group for Hematopoietic Transplantation and Cellular Therapy (GETH-TC). Transplantation and cellular therapy 61.94 32 Beyond the Favorable-Risk Label: Sequential Measurable Residual Disease and KIT Variant Status in Pediatric Core-Binding Factor Acute Myeloid Leukemia. Annals of laboratory medicine 47.5
PATIENT-FRIENDLY SUMMARY

Clinical, Radiographic and Histopathological Analysis of Cemento-Ossifying Fibromas and Fibro-Osseous Lesions of the Oral and Maxillofacial Region: A 53-Year Retrospective Study and Update of Current Concepts.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic