RESEARCH PAPER ANALYSIS
Induction chemotherapy and molecular MRD influence outcomes in KMT2A-rearranged AML.
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ABSTRACT
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We analyzed 217 patients with KMT2A-rearranged acute myeloid leukemia (AML) in 2 large sequential randomized trials. Those randomized to FLAG-Ida (fludarabine, cytarabine, granulocyte colony-stimulating factor, idarubucin) had markedly lower rates of relapse than other chemotherapy regimens. Molecular measurable residual disease assessment after cycle 2 was strongly prognostic for relapse and death. The trials were registered at the ISRCTN Registry as AML17 ISRCTN55675535 and AML19 ISRCTN78449203.
SUPPORTING PAPER SET
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medRxiv : the preprint server for health sciences
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Frontiers in pediatrics
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18
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The complications of irradiation or busulfan for CAYA before hematopoietic stem cell transplantation: a systematic review and meta-analysis.
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20
Analysis of factors influencing HPV vaccination willingness of parents of students in China based on the theory of planned behavior.
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Caregiver knowledge and Attitudes toward Human Papillomavirus Vaccination among adolescent girls living with HIV in Sierra Leone: A health facility-based cross-sectional study.
medRxiv : the preprint server for health sciences
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28
Invasive mechanical ventilation, functional decline at pediatric intensive care unit discharge, and post-discharge mortality in critically ill pediatric cancer patients: a retrospective cohort study.
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30
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