← Back to all signals
RESEARCH PAPER ANALYSIS

TRK Inhibitors in Adult and Pediatric High-Grade Gliomas: A Systematic Review and Individual Participant Data Meta-Analysis.

AI interpretation is pending for this paper.

Open original publication →
PMID40647390
JournalCancers
Publication Date2025-06-23
Ingested2026-08-02 12:04 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

BACKGROUND: High-grade glioma (HGG) is the most common primary malignant brain tumor, with peak incidence in the fifth and sixth decades of life. Although HGG is rare in children, the prognosis remains poor, with a median overall survival (OS) of less than two years. Recently, TRK inhibitors have been approved for the treatment of tumors harboring NTRK gene fusions. In this review, we analyzed data from early clinical trials investigating the use of these agents in patients with HGG. METHODS: A systematic literature search was performed in the PubMed database. Studies involving patients with HGG treated with TRK inhibitors were included. We analyzed progression-free survival (PFS), 24-week disease control rate, and complete or partial radiological responses according to the Response Assessment in Neuro-Oncology (RANO) criteria. RESULTS: Sixteen studies comprising 55 patients with HGG harboring NTRK gene fusions (19 adults and 36 children) were included. A statistically significant difference in PFS was observed between pediatric and adult patients treated with TRK inhibitors (17 vs. 8.5 months; p < 0.001). Pediatric patients also exhibited a higher rate of complete or partial radiological response compared to adults (94% vs. 57%). DISCUSSION: Although the available evidence on TRK inhibitors in HGG is limited, the findings of this review highlight a potentially promising role for these agents, particularly in the treatment of pediatric HGGs.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 [Surgical treatment of anterior visual pathway gliomas in children using intraoperative neurophysiological monitoring and MR tractography]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 59.24 2 [Desmoplastic infantile gangliogliomas/astrocytomas: clinical course, surgery and morphological diagnosis]. Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko 57.5 3 Donor-source-specific competing risks of relapse and non-relapse mortality in adult B-ALL allogeneic hematopoietic stem cell transplantation on a rabbit antithymocyte globulin-based platform. Annals of hematology 69.12 4 Thoracic Pathologies Requiring Surgical or Interventional Management in Solid-Organ Transplant Recipients. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 69.1 5 Erythema Multiforme after Liver Transplant: A Rare Pediatric Case Report. Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 52.3 6 Population-Level Associations of Diabetes Prevalence and Childhood Overweight with Kidney Cancer Mortality in Türkiye. Journal of clinical medicine 37.0 7 A Mechanistic Map of the Phenotypic Complexity in Recessive Dystrophic Epidermolysis Bullosa Provides Basis for Therapeutic Target Discovery and Drug Repurposing. International journal of molecular sciences 62.4 8 AAV9 Gene Therapy for Ovarian Dysfunction and Reproductive Aging: Molecular Mechanisms, Therapeutic Targets, and Translational Perspectives. International journal of molecular sciences 52.21 9 Cytomegalovirus Retinitis Across the Immunosuppression Spectrum: A Contemporary Framework for Risk Stratification, Diagnosis, and Vision-Preserving Therapy. Journal of clinical medicine 63.84 10 Digital 3D Technology in Pediatric Surgical Oncology: An Expert White Paper. Cancers 58.4 11 Maternal Gestational Hypertension Is Associated with Reduced TSG-6 in Human Milk: Potential Implications for Neonatal Immunological Support. International journal of molecular sciences 52.4 12 Enrichment-Free Rare Cell Profiling in Pediatric Osteosarcoma Reveals a Circulating Cell Population Associated with Relapse-Free Survival. Cancers 63.74 13 Treatment Outcomes and Prognostic Factors in Children with Myeloid Leukemia Associated with Down Syndrome: A Nationwide Polish Retrospective Study. Journal of clinical medicine 65.94 14 Unveiling the Role of [18F]FDG PET/CT in NUT Carcinoma: Insights from a Case Series and Literature Review. Diagnostics (Basel, Switzerland) 60.7 15 Development and Initial Validation of High-Fidelity 3D Hybrid Simulators for Training in Complex Pediatric Oncologic Surgery. Cancers 59.5 16 H3K27M Mutation Modulates the Antigenic Landscape in Diffuse Midline Glioma. Cancers 60.0 17 Advanced Drug Delivery in Pediatric Neurology: Developmental Barriers, Nanocarrier Strategies, and Translational Challenges. International journal of molecular sciences 66.36 18 Occurrence and Severity of Mental Health Disorders Among Patients Treated for Malignant Neoplasms: A Narrative Review with Preliminary Quantitative Synthesis. Journal of clinical medicine 75.4 19 Occult Neoplasms in Sudden Unexpected Death in Infancy: A Scoping Review of Post-Mortem Findings. Diagnostics (Basel, Switzerland) 58.5 20 Clinical Predictors of Surgical Intervention and Ovarian Torsion in Adolescents With Ovarian Cystic Lesions. The journal of obstetrics and gynaecology research 69.7 21 Clinical and Genetic Characterization of Russian Patients with von Hippel-Lindau Syndrome. International journal of molecular sciences 57.5 22 Nursing Perspectives on Palliative and Supportive Care in Paediatric Oncology: A Multicentre Qualitative Study. Nursing open 59.9 23 Astrovirus Gastroenteritis Mimicking Necrotizing Enterocolitis in a Pediatric Liver Transplant Recipient: A Case Report and Successful Conservative Management. Pediatric transplantation 54.3 24 Understanding vaccination against human papillomavirus (HPV): knowledge and perceptions among parents or guardians and healthcare workers, Germany, 2023. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin 59.2 25 Developing a Dual-Targeting CD33/CD70 CAR T-Cell Strategy Against Acute Myeloid Leukemia to Overcome Tumor Heterogeneity. Cancers 58.5 26 Minor Myeloid Leukemic Populations in Pediatric Acute Lymphoblastic Leukemia: A Potentially Underrecognized Mixed-Phenotype Tumor? International journal of molecular sciences 65.4 27 A Rare Case of Benign-Appearing Myoepithelial Carcinoma of the Hard Palate in an Adolescent. Journal of clinical medicine 56.0 28 18β-Glycyrrhetinic Acid Exerts Subgroup-Specific Antitumor Activity and Enhances Radiosensitivity in Medulloblastoma. Cancers 60.4 29 The Osteosarcoma Tumor Microenvironment: Supportive of Tumor Progression, Hostile to Immunity, but Therapeutically Targetable. Cancers 71.14 30 Radiation-Induced Contrast Enhancement After Proton Therapy for Paediatric Brain Tumours: Association with Variable Relative Biological Effectiveness and Linear Energy Transfer. Cancers 66.14 31 Development and temporal validation of an interpretable prediction model for 30-day meningitis or ventriculitis after pediatric brain tumor surgery: An 895-patient cohort study. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology 63.5 32 Megakaryopoiesis and its dysregulation in paediatric acute megakaryoblastic leukaemia. Leukemia research 62.4
PATIENT-FRIENDLY SUMMARY

TRK Inhibitors in Adult and Pediatric High-Grade Gliomas: A Systematic Review and Individual Participant Data Meta-Analysis.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic