Update on Adrenocortical Carcinoma.
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Adrenocortical carcinoma (ACC) is an uncommon and highly aggressive form of cancer that originates from the adrenal glands. It displays a dual age distribution pattern, with a higher occurrence during early childhood around the average age of 3.2 years, and a second peak in the fourth and fifth decades of adulthood. The diagnosis of ACC requires a multifaceted approach, with accurate risk assessment being crucial for effective treatment planning. This review article offers a comprehensive overview of ACC, encompassing its epidemiology, clinical presentation, diagnosis, prognostic factors, and treatment methodologies.