Human Papillomavirus Prevalence and Genotype Distribution Among Women With Cervical Cytological Abnormalities in Urumqi, Xinjiang, China.
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OBJECTIVE: To investigate the genotype distribution and viral loads of human papillomavirus (HPV) among women with cervical cytological abnormalities in Urumqi, Xinjiang, China. METHODS: The HPV genotyping and viral loads were detected in 9351 patients who underwent the ThinPrep cytology test (TCT) using quantitative real-time polymerase chain reaction. RESULT: The overall HPV infection rate was 21.63%, with a predominance of single and high-risk HPV (hrHPV) infection. The ethnic stratification showed that the infection rates were 17.01% (265/1558) in Uyghur, 21.76% (84/386) in Kazakh, 22.20% (103/464) in Hui, and 22.79% (1490/6539) in Han. The major hrHPV genotype was HPV53 in Kazakh and HPV16 in Uyghur, Han, and Hui ethnic groups. The age-stratified data suggested that the highest HPV infection rate in Han, Hui, and Kazakh women was among 25-34 year-olds, but in the 35-44 year-old group for Uyghur. The infection rates of HPV16 in cervicitis, ASCUS, LSIL, and HSIL groups were significantly different among the five ethnic groups; the viral load of HPV16 showed a positive correlation with the severity of cervical lesions. CONCLUSION: Variations exist in HPV infection and age distribution among different ethnic groups in Xinjiang, while the HPV16 viral load can guide risk stratification of cervical lesion progression.