RESEARCH PAPER ANALYSIS
A prospective cohort study on the trajectory of health-related quality of life in adult childhood cancer survivors attending a follow-up care program.
AI interpretation is pending for this paper.
Open original publication →EXECUTIVE SUMMARY
What the AI sees
Not AI summarized yet.
WHY IT MATTERS
Research significance
Pending deeper interpretation.
ABSTRACT
Source abstract
Follow-up care in adult childhood cancer survivors (ACCS) aims to screen for, prevent, and treat potential late effects. The trajectory of ACCS' health-related quality of life (HRQoL) attending follow-up care is unclear. We investigated changes in HRQoL of ACCS attending a follow-up care program. The primary outcome was the minimal clinically important decrease (MCID) in HRQoL of ≥ 5 points in the mental (MCS) and/or physical component score (PCS) of the 36-item Short Form (SF-36) between baseline and follow-up (3-months after the first visit). We compared baseline characteristics, psychological factors, satisfaction, and distress (measured using the Brief Symptom Inventory). In 47 ACCS (100%), no significant change in the overall median MCS and PCS was observed. In 14 ACCS (29.8%) a MCID in HRQoL was observed. Compared to ACCS without a MCID, they reported lower PCS (median 45.2 [31.7; 51.4] vs. 55.6 [46.1; 57.6], p = 0.007), a higher proportion of low physical health (PCS < 48; 71.4% vs. 27.3%, p = 0.009) and distress (50% vs. 18.8%, p = 0.030) at baseline. Satisfaction was high (94.9%). One in three ACCS experienced a clinically important decrease in HRQoL after follow-up care, with higher rates in those with lower physical health and higher psychological distress at baseline.
SUPPORTING PAPER SET
32 more papers to review
1
HMGA2-Rearranged Lipoblastoma in an Adult Patient With Novel GRIP1 Gene Fusion Partner.
Cureus
54.0
2
AGK::BRAF fusion activates MAPK signaling, promotes genomic instability, and reduces NIS expression in thyroid cancer cells.
Endocrine oncology (Bristol, England)
56.0
3
Comparison of Remimazolam and Propofol for Anesthesia Management in Liver Cancer Patients Undergoing Percutaneous Radiofrequency Ablation: A Randomized Controlled Trial.
Drug design, development and therapy
80.6
4
Radiological signatures and health risks of natural radionuclides in the Nubian Sandstone Aquifer across Egypt's Western Desert oases.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
58.7
5
[Analysis of risk factors for pathological upgrading after cervical conization in patients with CIN1].
Zhonghua fu chan ke za zhi
65.4
6
Hypothalamic obesity in pediatric vs. adult craniopharyngioma: mechanisms, management, and cardiometabolic outcomes.
Pituitary
65.05
7
Engineered Peptide Self-Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
60.12
8
Leukemia cutis exhibiting Darier's sign: a rare presentation of acute monoblastic leukemia.
Acta dermatovenerologica Alpina, Pannonica, et Adriatica
55.2
9
Real-world outcomes of nivolumab-AVD and brentuximab vedotin-AVD in paediatric and adult advanced-stage Hodgkin lymphoma.
British journal of haematology
75.9
10
Atypical Case of Presumed Bartonella henselae Osteomyelitis in a Child with Cat-Scratch Disease Mimicking a Malignant Bone Tumor.
Children (Basel, Switzerland)
56.2
11
Gait and Functional Movement Quality Improvements Following an Individualized Exercise Program in Pediatric Hemato-Oncological Patients.
Children (Basel, Switzerland)
57.0
12
Scaling Adolescent Immunity: Multi-Age Cohort Human Papillomavirus (HPV) Vaccination Campaigns in West Africa-Evidence from Côte d'Ivoire, Ghana, Liberia, and Sierra Leone.
Vaccines
59.9
13
CNN Sample-Size Effects Across Biomedical Datasets: A Reliability Pattern in Overfitting, Ranking, and Monotonicity.
Bioengineering (Basel, Switzerland)
57.5
14
Psychological Assessment of Parenting Stress and Emotional Support: A Moderated Mediation Model of Psychological Distress and Well-Being Among Childbearing-Age Women with Thyroid Cancer.
Behavioral sciences (Basel, Switzerland)
41.5
15
Infected Urachal Cyst Presenting as a Huge Abdominal Abscess in an Elderly: A Case Report.
Cureus
47.5
16
Metastatic Retroperitoneal Rhabdomyosarcoma in a Child: A Case Report Highlighting the Role of Imaging in Diagnosis, Staging, and Follow-Up.
Cureus
65.5
17
Consumer Risk Characterisation of Potentially Toxic Elements in European Seabass (Dicentrarchus labrax) Marketed in Hungary.
Toxics
40.5
18
Dynamic Metabolic Parameters and Deauville Score on 18F-FDG PET/CT for Prognostic Assessment in Pediatric Burkitt Lymphoma.
Children (Basel, Switzerland)
72.3
19
Clinical and Dermoscopic Determinants of Surgical Decision-Making in Skin Cancer Screening: A Retrospective Analysis.
Medicina (Kaunas, Lithuania)
65.0
20
The Oral and Nasal Gateway Microbiomes: Salivaomics and Systemic Health at the Airway-Digestive Interface.
Microorganisms
58.0
21
Knowledge and Perceptions of Human Papillomavirus Infection and Vaccination Among Adolescents in French Rural Family Homes: A Mixed-Methods Study.
Vaccines
68.7
22
Study of Telomere Length Kinetics and Telomerase Reverse Transcriptase Gene Polymorphism in Children Undergoing Allogeneic Haematopoietic Stem Cell Transplantation.
Genes
58.7
23
Familial florid cemento-osseous dysplasia in two young sisters: case report and literature review.
British dental journal
52.3
24
Laparoscopic Wilms Tumor Nephrectomy and Lymph Node Sampling: Oncotechnical Considerations.
Journal of Indian Association of Pediatric Surgeons
63.4
25
Xanthogranulomatous Orchitis Masquerading as Chronic Epididymo-orchitis in a Paediatric Patient.
Journal of Indian Association of Pediatric Surgeons
58.0
26
Dermatofibrosarcoma Protuberans of the Scalp in a 15-year-old Boy: A Rare Pediatric Surgical Challenge.
Journal of Indian Association of Pediatric Surgeons
43.0
27
An Analysis of Multilevel Barriers to Human Papillomavirus Vaccination Uptake Among Rural U.S. Adolescents.
Vaccines
58.0
28
Health-Related Quality of Life in Children with Acute Leukaemia and Central Nervous System Tumours: Current Evidence and Future Directions.
Children (Basel, Switzerland)
61.6
29
Clinical Characteristics and Antimicrobial Resistance Profiles of Pediatric Enterococcal Infections: A Comparison Between Enterococcus faecium and Enterococcus faecalis.
Pathogens (Basel, Switzerland)
69.4
30
Precision Medicine in Pediatric Nephrology: From Shared Clinical Phenotypes to Genotype-Guided Diagnosis and Management.
Genes
68.44
31
Adolescent Helicobacter pylori Screening for Gastric Cancer Prevention: Current Evidence and Future Perspectives.
Children (Basel, Switzerland)
61.4
32
Novel Homozygous LAMC3 Frameshift Variant Associated with Confluent Leukoencephalopathy and Low-Grade Tectal Glioneuronal Tumor: Expanding the Phenotypic Spectrum with Bioinformatic Characterization.
Life (Basel, Switzerland)
56.0