← Back to all signals
RESEARCH PAPER ANALYSIS

Salpingectomy With Delayed Oophorectomy Versus Salpingo-Oophorectomy in BRCA1/2 Carriers: Three-Year Outcomes of a Prospective Preference Trial.

AI interpretation is pending for this paper.

Open original publication →
PMID39823150
JournalBJOG : an international journal of obstetrics and gynaecology
Publication Date2025-01-17
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

OBJECTIVE: To compare menopause-related quality of life (QoL) after risk-reducing salpingectomy (RRS) versus risk-reducing salpingo-oophorectomy (RRSO) until 3 years of post-surgery. DESIGN: A prospective study (TUBA study) with treatment allocation based on patients' preference. Data were collected pre-surgery and at 3 months, 1 and 3 years of post-surgery. SETTING: Multicentre prospective preference trial in thirteen hospitals in the Netherlands. POPULATION: BRCA1/2 pathogenic variant (PV) carriers aged 25-40 (BRCA1) or 25-45 (BRCA2), who were premenopausal, without a future child wish and without current (treatment for) malignancy. METHODS: Treatment allocation was based on patients' preference: either RRS from the age of 25 years with delayed oophorectomy at the maximum age of 45 (BRCA1) or 50 (BRCA2), or RRSO between the ages of 35-40 (BRCA1) or 40-45 (BRCA2). After RRSO, hormone replacement therapy (HRT) was recommended, if not contraindicated. Primarily, menopause-related QoL as measured with the Greene Climacteric Scale (GCS) was compared between the RRS and RRSO without HRT group. Secondarily, GSC-scores of the RRS group were compared with the scores of the RRSO with HRT after surgery group. A higher GSC-score reflects more climacteric symptoms. RESULTS: Until April 2023, 410 participants had undergone RRS and 160 RRSO. The BRCA1/BRCA2 proportions were 51.4%/48.6%. The mean age at surgery (SD) was 37.9 (3.5) years. Participants 3 years after RRSO without HRT had a 4.3 (95% CI 2.1-6.5; p < 0.001) point higher increase in GCS-score from baseline compared to those after RRS, while the difference was 7.9 (95% CI 5.9-9.8) and 8.5 (95% CI 6.5-10.5) points at 3 and 12 months, respectively. Among participants with HRT after surgery, the RRSO group had a 2.4 (95% CI 0.8-3.9; p = 0.002) point higher increase in GCS-score from baseline compared to the RRS group. CONCLUSIONS: In this multicentre preference trial, menopause-related QoL was better after RRS than after RRSO, even with HRT after RRSO. Differences between arms were most pronounced until one-year post-surgery.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Hypothalamic obesity following craniopharyngioma surgery: What is the role of hypothalamic T2 signal changes in brain MRI? Neuro-oncology advances 61.9 2 Personalized Perioperative Music Listening: A Human-Centered Approach to Precision Anesthesia. Cureus 74.2 3 Adult Congenital Pulmonary Airway Malformation Presenting With a Large Cystic Lung Lesion: A Case Report. Cureus 47.5 4 Spinal Myeloid Sarcoma Revealing Acute Myeloid Leukemia in a Child: A Case Report. Cureus 54.3 5 A Non-enhanced CT Dataset for Differential Diagnosis of Pediatric Extracranial Germ Cell Tumors. Scientific data 57.0 6 Female cancers in adolescent and young adult women: global inequities and 2050 burden estimates from GLOBOCAN 2022. Frontiers in oncology 61.1 7 Knowledge of cervical cancer screening, barriers to awareness, and the role of technological interventions in improving screening uptake: a scoping review protocol. Frontiers in health services 78.8 8 Resources are associated with functional outcome and brain morphometry in childhood cancer survivors. Frontiers in oncology 63.9 9 Immunogenicity, efficacy, and safety of different dose schedules of human papillomavirus vaccines: a Bayesian network meta-analysis of randomized controlled trials. Frontiers in immunology 81.32 10 Case Report: Synchronous ALK-positive laryngeal inflammatory myofibroblastic tumor and EGFR-mutant lung adenocarcinoma in a child. Frontiers in pediatrics 48.5 11 Case Report: Anti-GQ1b antibody-positive overlap syndrome: a pediatric case involving the brainstem, spinal cord, and peripheral nerves. Frontiers in immunology 59.66 12 Hunger, satiety, and eating behavior after craniopharyngioma - narrative review on current management and future therapeutic perspectives. Frontiers in endocrinology 82.34 13 Awareness and Acceptance of the Human Papillomavirus (HPV) Vaccine and Associated Factors Among Parents of Adolescents (9-18 Years) at a Children's Hospital in Babol, Iran: A Cross-Sectional Study. Health science reports 63.7 14 Long-term complications after total body irradiation in children younger than 4 years transplanted for acute lymphoblastic leukemia. Bone marrow transplantation 62.4 15 Fertility and Birth Outcomes in Rheumatoid Arthritis: A Narrative Review. Rheumatology and therapy 63.6 16 Characteristics and outcome of T-cell/histiocyte-rich large B-cell lymphoma in childhood and adolescence: An international retrospective analysis. British journal of haematology 28.5 17 Benign and Malignant Conjunctival Lesions in Children. Seminars in ophthalmology 51.5 18 Clinical characteristics, management and outcomes in immune checkpoint inhibitor-induced central nervous system demyelinating disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 85.76 19 Preoperative Speech Impairments as Precursors of Posterior Fossa Syndrome in Children with Brain Tumours. Cerebellum (London, England) 65.9 20 Invasive Fusarium Infections in Immunocompromised Children: A 10-year Multicenter Retrospective Study and Literature Review. The Pediatric infectious disease journal 76.5 21 Rhabdomyosarcoma Mimicking Otomastoiditis in a Preschool Child with Facial Paralysis. Ear, nose, & throat journal 56.0 22 Cyst wall enhancement is associated with local recurrence after resection of intracranial hemangioblastoma: an exploratory retrospective cohort study. Journal of neuro-oncology 64.7 23 Correction to "Single-Cell RNA Sequencing Reveals the Heterogeneity in Differentiation Trajectory and Tumor Microenvironment Leading to More Aggressive Phenotypes of Papillary Thyroid Cancer in Children and Young Adult Patients". Advanced science (Weinheim, Baden-Wurttemberg, Germany) 47.5 24 Erratum. International archives of allergy and immunology 89.0 25 The Childhood Cancer and Leukemia International Consortium (CLIC): Expanding global collaboration in pediatric cancer etiology research. Cancer epidemiology 64.2 26 Aminosalicylate use Increases Corticosteroid Exposure and Decreases Biologic Durability in Pediatric Crohn's Disease. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 68.3 27 Inadequate Energy and Micronutrient Intakes Across Filipino Population Groups: Findings from the 2021 Expanded National Nutrition Survey (ENNS). The Journal of nutrition 67.5 28 Paediatric tracheal carcinoid with carinal involvement and nodal metastasis: challenging airway reconstruction with oncological clearance. BMJ case reports 56.0 29 Acute abdomen in pregnancy revealing sigmoid colon carcinoma at caesarean section. BMJ case reports 58.4 30 Archegonous cystic odontoma: expanding the spectrum of hybrid odontogenic lesions. BMJ case reports 56.0 31 Selective retinal arterial whitening in retinal astrocytic hamartoma in tuberous sclerosis. BMJ case reports 48.5 32 Appendicovesical fistula in a child with acute myeloid leukaemia. BMJ case reports 47.9
PATIENT-FRIENDLY SUMMARY

Salpingectomy With Delayed Oophorectomy Versus Salpingo-Oophorectomy in BRCA1/2 Carriers: Three-Year Outcomes of a Prospective Preference Trial.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic