← Back to all signals
RESEARCH PAPER ANALYSIS

Cytokine Profiles Associated With Clinical Outcomes in Pediatric Patients With Meningitis: A Systematic Review and Meta-Analysis.

AI interpretation is pending for this paper.

Open original publication →
PMID39784111
JournalJournal of child neurology
Publication Date2025-01-09
Ingested2026-08-02 12:03 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

This review evaluated the correlation between inflammatory response and clinical outcomes in pediatric patients with meningitis. PubMed, Scopus, and Web of Science were searched for relevant studies published until March 2024. A total of 139 articles were identified; 7 studies were eligible, and 3 provided data for the meta-analysis. All included articles comprised one of the following cohorts: children with bacterial meningitis, those with aseptic meningitis, or febrile children without evidence of central nervous system infection. The following cytokines and chemocytokines were assessed: interleukin IL-1β, IL-6, IL-17, tumor necrosis factor-alpha, and transforming growth factor-beta 1. Studies on children with bacterial meningitis confirmed by culture found that acute complications and neurologic sequelae were associated with higher concentrations of IL-1β, IL-6, and IL-17. Although this review could not definitively correlate individual inflammatory responses with the prognosis of children with central nervous system infections, IL-6 from cerebrospinal fluid may potentially predict the prognosis of children with bacterial meningitis.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Plasma Cell Gingivitis With Cheilitis in an Adolescent: A Case Report. Cureus 51.1 2 Efgartigimod as a salvage therapy for anti-NMDAR encephalitis patients after first-line treatment failure: a case series. Frontiers in neurology 65.18 3 Successful treatment of refractory classic juvenile pityriasis rubra pilaris with adalimumab in a 4-year-old girl: a case report. Frontiers in immunology 67.0 4 Clinical spectrum and survival outcomes of malignancies in pediatric patients with inborn errors of immunity. Frontiers in immunology 65.82 5 Therapy-related acute myeloid leukemia with 24-month latency after CD19 CAR-T cell therapy in relapsed/refractory diffuse large B-cell lymphoma: a case report. Frontiers in medicine 63.86 6 HPV52 predominates in cervical infections and precancerous lesions in Chongqing, China: a 6-year study linking genotypes to vaginal microecology. Frontiers in public health 61.9 7 Report from the National Pediatric Cancer Foundation - infantile glioma and other non-embryonal central nervous system tumors: evolving molecular advances and current treatment landscape. Frontiers in oncology 68.34 8 Targeted immunotherapies for anaplastic lymphoma kinase-positive pediatric tumors: current advances and future perspectives. Frontiers in immunology 87.5 9 The real-world practice of fertility preservation for patients with epithelial ovarian cancer in Asian regions. Journal of gynecologic oncology 67.2 10 Multiple congenital dermal sinus tracts: a case-based review involving a unique triple-tract configuration that challenges current embryological concepts. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery 49.9 11 Natural products mediate ferroptosis and immune microenvironment-linked sensitization in osteosarcoma: from chemotherapy resistance to combined therapeutic transformation. Molecular diversity 71.38 12 Age-associated epigenomic heterogeneity in papillary tumors of the pineal region: a multicenter YoungNOA investigation. Acta neuropathologica communications 66.6 13 Pediatrics supratentorial intraventricular atypical teratoid/rhabdoid tumors: a case report and a systematic review of the literature. European journal of pediatrics 77.1 14 Cranial pathologies in Noonan syndrome: clinical implications for pre-growth hormone neuroimaging. European journal of pediatrics 61.4 15 Narciclasine reduces proliferation and migration of neuroblastoma cells and decreases FAK/PI3K pathway activation. Medical oncology (Northwood, London, England) 43.0 16 Balancing safe resection and spinal stability in osteoblastoma and osteoid osteoma: a retrospective study. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie 67.4 17 Scaling up symptom screening for routine use in pediatric oncology: provincial implementation. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 61.6 18 Extent of resection and craniopharyngioma recurrence: a volumetric analysis. Journal of neuro-oncology 66.1 19 Fertility in breast cancer survivorship: a scoping review. Journal of cancer survivorship : research and practice 81.0 20 Clinical practice guideline for psoriasis management in Latin America. Anais brasileiros de dermatologia 76.5 21 Constrained Choices and Meaning-Making: A Qualitative Study of Caregivers of Children With Hematologic Malignancies. Psycho-oncology 59.6 22 Timely Surgical Approaches for Pediatric Epilepsy Resistant to Medication. Journal of surgery and research 64.0 23 The Journey with paediatric cancer: reflections on its impact on patients and their families. The Pan African medical journal 56.0 24 Pars plana vitrectomy in uveitis of diverse etiologies: indications and surgical outcomes. BMC ophthalmology 63.5 25 Persistent Oropharyngeal Hemangioma Causing Progressive Upper Airway Compromise: Diagnostic and Therapeutic Challenges. Cureus 61.64 26 Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment, and follow-up of patients with hepatocellular carcinoma. ESMO open 71.84 27 Life Saving Hepatic Resections in Ruptured Pediatric Hepatoblastoma - a Report of 3 Cases. Indian journal of surgical oncology 63.6 28 Development and Internal Validation of the SPR-HCC Score System: A Prognostic Tool for Survival Prediction in Hepatocellular Carcinoma in a Resource-Limited Setting. Asian Pacific journal of cancer prevention : APJCP 72.02 29 Retinoblastoma Incidence in Saudi Arabia: A 20-Year Analysis. Asian Pacific journal of cancer prevention : APJCP 57.5 30 Systemic Immune Inflammation Index as High-Risk Retinoblastoma Survival Predictor. Asian Pacific journal of cancer prevention : APJCP 63.12 31 Predictors of Cervical Cancer Screening Uptake Among Women of Reproductive Age in Indonesia: A Nationwide Cross-Sectional Study Based on the 2023 Indonesian Health Survey. Asian Pacific journal of cancer prevention : APJCP 67.5 32 Effects of estetrol/drospirenone vs drospirenone-only on thrombin generation in women with polycystic ovary syndrome: a randomized, double-blind, controlled trial. Research and practice in thrombosis and haemostasis 77.6
PATIENT-FRIENDLY SUMMARY

Cytokine Profiles Associated With Clinical Outcomes in Pediatric Patients With Meningitis: A Systematic Review and Meta-Analysis.

For education only—not personal medical advice.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic