← Back to all signals
RESEARCH PAPER ANALYSIS

Reduced levels of liver kinase B1 in small extracellular vesicles as a predictor for chronic lung allograft dysfunction in cystic fibrosis lung transplant recipients.

AI interpretation is pending for this paper.

Open original publication →
PMID39612537
JournalHuman immunology
Publication Date2024-11-28
Ingested2026-08-02 12:02 AM
EXECUTIVE SUMMARY

What the AI sees

Not AI summarized yet.

WHY IT MATTERS

Research significance

Pending deeper interpretation.

ABSTRACT

Source abstract

Small extracellular vesicles (sEVs) isolated from plasma of lung transplant recipients (LTRs) with chronic lung allograft dysfunction (CLAD) contain increased levels of lung associated self-antigens, Kα1 tubulin and collagen V, and decreased expression of the tumor suppressor liver kinase B1 (LKB1). In this study, sEVs were isolated from plasma collected from LTRs with or without cystic fibrosis (CF) from multiple centers at the onset of CLAD and 6 and 12 months before clinical diagnosis of CLAD (n = 32) as well as from time-matched stable controls (n = 25). sEVs were analyzed for Kα1 tubulin, collagen V, and LKB1 by western blot. Exoview R200, a functionalized microarray chip was employed to characterize the LKB1 in sEVs. EVs from non-CF LTRs had higher levels of lung self-antigens (p < 0.05) and lower levels of LKB1 (p = 0.024) 12 months before CLAD diagnosis than those from time-matched stable LTRs; however, in CF LTRs, only LKB1 levels were lower (p = 0.0005) 6 months before diagnosis. Further characterization of sEVs 6 months before CLAD in CF LTRs also demonstrated significantly lower numbers of LKB1 and LKB1/CD9 + sEV particles. Reduced LKB1 in circulating sEVs offers a potential biomarker for the risk of CLAD in LTRs with CF.

SUPPORTING PAPER SET

32 more papers to review

Ranked by current scoring engine
1 Clinical characteristics and outcome of patients with craniopharyngioma followed up at a tertiary Endocrine Unit in Sri Lanka; Cross-Sectional study. The Ceylon medical journal 63.4 2 Primary Hepatic Neuroblastoma: A Case Report of a Solitary Liver Mass in an Adolescent Male. Cureus 51.9 3 Embryonic origin of cancer in newborn twins. Nature communications 35.0 4 Jejunal B-Cell Non-Hodgkin Lymphoma Presenting with a Long Stenosing Lesion in an Adolescent: A Case Report. Cancer management and research 51.9 5 Biomaterial-Enabled Delivery Strategies to Overcome Treatment Resistance in Medulloblastoma. International journal of nanomedicine 68.04 6 Van Neck-Odelberg Disease in a Pediatric Patient With Prolonged Groin Pain: A Case Report. Case reports in radiology 51.4 7 Chronic disease burden and health-related quality of life among missouri adults. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation 65.0 8 Increased Incidence and Improved Survival of Ewing and Ewing-Like Sarcomas in Children and Young Adolescents in the Netherlands Since the 1990s: A Population-Based Study. Cancer medicine 68.32 9 [Clinicopathological study of YAP1-fusion positive supratentorial ependymoma]. Zhonghua bing li xue za zhi = Chinese journal of pathology 28.5 10 Extreme Thrombocytosis in Patients With Malignancy; Complications, Management and Outcomes. EJHaem 75.0 11 Effect of a free sugar-restricted diet on anthropometric parameters, lipid profile, and glycemic control in women with polycystic ovary syndrome: a randomized controlled trial. BMC endocrine disorders 78.0 12 Clinico-pathologic Evaluation of Patients with Hemangioendothelioma: A 10-year Experience from Shiraz, Southern of Iran : Short title: Clinicopathologic evaluation of hemangioendothelioma. Galen medical journal 69.0 13 Intramedullary Spinal Tuberculosis Mimicking Neoplasm with Ocular Involvement in an Adolescent: A Case Report. Iranian journal of child neurology 49.9 14 Excess mortality related to the COVID-19 pandemic by age, sex, and cause of death in the Czech Republic. BMC public health 57.5 15 Normal on the Inside: A Case of Recurrent Abdominal Pain, Equivocal CT Appendicitis, and Histologically Normal Appendix in an Adolescent With Chronic Cannabis Use. Cureus 47.5 16 Self-reported oral health-related quality of life among pediatric oncology patients: a cross-sectional study at Kenyatta National Hospital, Kenya. Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD 61.4 17 Case Report: Intracranial germ cell tumors in girls presenting with peripheral precocious puberty and arginine vasopressin deficiency. Frontiers in endocrinology 56.3 18 Rectal colonization with multidrug-resistant organisms in adult acute leukemia patients undergoing allogeneic hematopoietic stem cell transplantation: a retrospective, longitudinal, single-center study. Frontiers in cellular and infection microbiology 72.76 19 Artificial intelligence-enabled nursing surveillance for pediatric cancer immunotherapy: integrating biomarkers, patient-reported outcomes, and long-term toxicity management. Frontiers in medicine 74.0 20 Double heterozygous pathogenic germline APC and MSH2 variants in a 16-year-old female diagnosed with colorectal cancer. Familial cancer 56.0 21 Ferroptotic stress selectively enhances ACSL4 translation during global translational repression in glioblastoma models. Molecular biology reports 58.2 22 Cured but What's Next? Rethinking Survivorship Care for Adolescent and Young Adult Testicular Cancer Survivors. European urology oncology 79.0 23 Dietary patterns and cardiovascular risk in adult survivors of childhood cancer: findings from the SCCSS-Nutrition Study. Journal of cancer survivorship : research and practice 56.0 24 SJIP38: A single-tube 38-parameter spectral immunophenotyping panel for the lineage classification of pediatric leukemias. Cytometry. Part B, Clinical cytometry 57.2 25 Divergent Trends in Head and Neck Cancer Burden in China (1990-2021). Asia-Pacific journal of clinical oncology 61.6 26 Low albumin levels precede mucormycosis in pediatric cancer patients. Medical mycology 63.9 27 Variance decomposition of probabilistic health risk of potentially toxic metals at two Nigerian artisanal mining fields. Environmental geochemistry and health 57.5 28 High school students' perspectives on childhood cancer: A metaphorical analysis. Journal of pediatric nursing 57.2 29 Antibody-drug conjugates in the treatment of Leukemia: a constraint-satisfaction heuristic analysis of global clinical trials. Translational oncology 68.56 30 Determinants of Systemic Anticancer Treatment and Continuous Intravenous Opioid and/or Benzodiazepine Use at End of life: A Real-World Analysis of Demographic and Clinical Factors in Advanced Cancer Patients. Clinical medicine (London, England) 79.04 31 Comment on "Understanding the Immune Response Changes to Clinical Interventions for Epstein-Barr Virus Infection Prior to Lymphoma Development in Children After Organ Transplants (UNEARTH)". Pediatric transplantation 51.82 32 Paediatric chronic hepatitis C and the global elimination gap: burden and trends from 1990 to 2023 in the Global Burden of Disease Study 2023. EClinicalMedicine 59.9
PATIENT-FRIENDLY SUMMARY

Reduced levels of liver kinase B1 in small extracellular vesicles as a predictor for chronic lung allograft dysfunction in cystic fibrosis lung transplant recipients.

For education only—not personal medical advice.

Before you continue

AI-assisted research information

Neurocompute uses AI to summarize scientific papers, interpret research signals, and suggest relevant reference links. AI-generated content can be incomplete, misleading, or wrong, and generated links may be irrelevant or unavailable.

Our reviewed outputs have performed strongly to date, but past accuracy is not a guarantee. Verify summaries, scores, claims, and links against the original publication before relying on them.

This platform is for research and education only. It does not provide medical advice, diagnosis, treatment recommendations, or clinical guidance.

Pediatric cancer research intelligence graphic
PEDIATRIC CANCER VISUAL SYSTEM

Open the Research Intelligence Map

Explore the active pediatric oncology analysis view.

Expand Intelligence View →
Full Pediatric cancer research intelligence graphic